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Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells
Abstract Palygorskite (Pal), a natural clay mineral, grafted by functional macromolecule polyethyleneimine (PEI) via the coupling grafting method, has further been modified by introducing both fluorescein isothiocyanate (FI) and folic acid (FA), with the aim of specifically targeting and detecting cancer cells. The formed Pal-PEI–FI–FA nanocomposite was nontoxic up to a concentration of 300μg·mL−1, and further could be specially taken up by HeLa cells via FA receptor-mediated endocytosis as shown by confocal microscopy and inductively coupled plasma optical emission spectroscopy (ICP-OES) data. Therefore, it is concluded that the novel Pal-based nanocomposite has great potential for biomedical sensing, diagnosis, and therapeutics.
Graphical abstract Display Omitted
Highlights This is the first example of modifying one clay mineral for targeting cancer cells. The nanocomposite can be especially taken up by HeLa cells via folate receptors. The nanocomposite could be a promising nanoplatform loaded with drug molecules.
Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells
Abstract Palygorskite (Pal), a natural clay mineral, grafted by functional macromolecule polyethyleneimine (PEI) via the coupling grafting method, has further been modified by introducing both fluorescein isothiocyanate (FI) and folic acid (FA), with the aim of specifically targeting and detecting cancer cells. The formed Pal-PEI–FI–FA nanocomposite was nontoxic up to a concentration of 300μg·mL−1, and further could be specially taken up by HeLa cells via FA receptor-mediated endocytosis as shown by confocal microscopy and inductively coupled plasma optical emission spectroscopy (ICP-OES) data. Therefore, it is concluded that the novel Pal-based nanocomposite has great potential for biomedical sensing, diagnosis, and therapeutics.
Graphical abstract Display Omitted
Highlights This is the first example of modifying one clay mineral for targeting cancer cells. The nanocomposite can be especially taken up by HeLa cells via folate receptors. The nanocomposite could be a promising nanoplatform loaded with drug molecules.
Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells
Han, Shuai (author) / Liu, Feng (author) / Wu, Jiang (author) / Zhang, Yu (author) / Xie, Yujie (author) / Wu, Wenyu (author) / Liu, Weisheng (author) / Wang, Qin (author) / Tang, Yu (author)
Applied Clay Science ; 101 ; 567-573
2014-09-17
7 pages
Article (Journal)
Electronic Resource
English
Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells
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