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Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties
Abstract Clays have shown to be good candidates as drug delivery carriers. In the present paper, the temperature-dependent swelling of smectites was exploited to obtain composites able to release a drug in a controlled way. More specifically, synthetic fluorohectorite-ciprofloxacin composites were prepared, in which the drug molecules were intercalated between the clay layers. The drug-release systems were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermal gravimetric analysis (TGA), ultraviolet spectroscopy (UV) and atomic absorption spectrometry (AAS). The results from the X-ray diffraction allowed confirming the ciprofloxacin incorporation into the interlayer space, and the results from UV spectroscopy indicated that more than 90% of the initial drug was uptaken by the clay. The thermally activated drug release from a colloidal dispersion of nanosized composite particles in both pure water and synthetic gastric juice was evaluated at temperatures from 37°C (body temperature) to 85°C. The studies indicated that the clay promotes the slow release of ciprofloxacin, and that the release of drug increases with both time and temperature. The profiles of drug-release from the clay fulfilled the pharmaceutical standards for these systems. As a result, a clay-based Temperature-Controlled Release System (TCRS) with potential biomedical applications has been obtained.
Graphical abstract Ciprofloxacin (Cipro) incorporation into Li-fluorhectorite (LiFh) clay and its temperature-controlled release. Display Omitted
Highlights Intercalation of ciprofloxacin into a smectite with potential medical applications Structural characterization of the raw material and the clay-drug composites Temperature-controlled drug release abilities of a clay-drug composite
Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties
Abstract Clays have shown to be good candidates as drug delivery carriers. In the present paper, the temperature-dependent swelling of smectites was exploited to obtain composites able to release a drug in a controlled way. More specifically, synthetic fluorohectorite-ciprofloxacin composites were prepared, in which the drug molecules were intercalated between the clay layers. The drug-release systems were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermal gravimetric analysis (TGA), ultraviolet spectroscopy (UV) and atomic absorption spectrometry (AAS). The results from the X-ray diffraction allowed confirming the ciprofloxacin incorporation into the interlayer space, and the results from UV spectroscopy indicated that more than 90% of the initial drug was uptaken by the clay. The thermally activated drug release from a colloidal dispersion of nanosized composite particles in both pure water and synthetic gastric juice was evaluated at temperatures from 37°C (body temperature) to 85°C. The studies indicated that the clay promotes the slow release of ciprofloxacin, and that the release of drug increases with both time and temperature. The profiles of drug-release from the clay fulfilled the pharmaceutical standards for these systems. As a result, a clay-based Temperature-Controlled Release System (TCRS) with potential biomedical applications has been obtained.
Graphical abstract Ciprofloxacin (Cipro) incorporation into Li-fluorhectorite (LiFh) clay and its temperature-controlled release. Display Omitted
Highlights Intercalation of ciprofloxacin into a smectite with potential medical applications Structural characterization of the raw material and the clay-drug composites Temperature-controlled drug release abilities of a clay-drug composite
Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties
Rivera, A. (author) / Valdés, L. (author) / Jiménez, J. (author) / Pérez, I. (author) / Lam, A. (author) / Altshuler, E. (author) / de Ménorval, L.C. (author) / Fossum, J.O. (author) / Hansen, E.L. (author) / Rozynek, Z. (author)
Applied Clay Science ; 124-125 ; 150-156
2016-02-08
7 pages
Article (Journal)
Electronic Resource
English
Drug , Antibiotic , Smectite , Fluorohectorite , Clay
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