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Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
https://orcid.org/0000-0003-4277-818X
https://orcid.org/0000-0001-7525-4089
https://orcid.org/0000-0003-1095-5137
https://orcid.org/0000-0002-3326-2459
https://orcid.org/0000-0002-7391-5768
https://orcid.org/0000-0002-6933-5373
https://orcid.org/0000-0003-1405-9751
https://orcid.org/0000-0002-2112-6740
https://orcid.org/0000-0003-2716-9167
Graphical abstract Display Omitted
Highlights Few studies exist on prenatal POP exposure and preadolescent cardiometabolic health. Prenatal POP mixture is associated with higher body mass index and body fat mass. HCB and β-HCH are the main contributors to the POP mixture effect on adiposity. β-HCH and p,p'-DDE are associated with higher blood pressure in girls only.
Abstract Background Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. Methods This study included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (p,p′-Dichlorodiphenyldichloroethylene [p,p′-DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), percentage of fat mass, and blood pressure (mmHg) were measured at around 12 years of age. Single-exposure associations were studied using linear or logistic regressions, and the POP mixture effect was evaluated using quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and performed for boys and girls together and separately. Results Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These mixture effects were also statistically significant using BKMR. These associations were driven mainly by exposure to HCB and, to a lesser extent, to β-HCH. In addition, the single-exposure models showed an association between β-HCH and p,p′-DDE and higher systolic blood pressure, especially in girls (p,p′-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found for PCBs. Conclusion This study suggests that prenatal exposure to POPs, particularly organochlorine pesticides, remains associated with unfavorable cardiometabolic health up to the age of 12.
Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
https://orcid.org/0000-0003-4277-818X
https://orcid.org/0000-0001-7525-4089
https://orcid.org/0000-0003-1095-5137
https://orcid.org/0000-0002-3326-2459
https://orcid.org/0000-0002-7391-5768
https://orcid.org/0000-0002-6933-5373
https://orcid.org/0000-0003-1405-9751
https://orcid.org/0000-0002-2112-6740
https://orcid.org/0000-0003-2716-9167
Graphical abstract Display Omitted
Highlights Few studies exist on prenatal POP exposure and preadolescent cardiometabolic health. Prenatal POP mixture is associated with higher body mass index and body fat mass. HCB and β-HCH are the main contributors to the POP mixture effect on adiposity. β-HCH and p,p'-DDE are associated with higher blood pressure in girls only.
Abstract Background Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. Methods This study included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (p,p′-Dichlorodiphenyldichloroethylene [p,p′-DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), percentage of fat mass, and blood pressure (mmHg) were measured at around 12 years of age. Single-exposure associations were studied using linear or logistic regressions, and the POP mixture effect was evaluated using quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and performed for boys and girls together and separately. Results Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These mixture effects were also statistically significant using BKMR. These associations were driven mainly by exposure to HCB and, to a lesser extent, to β-HCH. In addition, the single-exposure models showed an association between β-HCH and p,p′-DDE and higher systolic blood pressure, especially in girls (p,p′-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found for PCBs. Conclusion This study suggests that prenatal exposure to POPs, particularly organochlorine pesticides, remains associated with unfavorable cardiometabolic health up to the age of 12.
Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
https://orcid.org/0000-0003-4277-818X
https://orcid.org/0000-0001-7525-4089
https://orcid.org/0000-0003-1095-5137
https://orcid.org/0000-0002-3326-2459
https://orcid.org/0000-0002-7391-5768
https://orcid.org/0000-0002-6933-5373
https://orcid.org/0000-0003-1405-9751
https://orcid.org/0000-0002-2112-6740
https://orcid.org/0000-0003-2716-9167
Graphical abstract Display Omitted
Highlights Few studies exist on prenatal POP exposure and preadolescent cardiometabolic health. Prenatal POP mixture is associated with higher body mass index and body fat mass. HCB and β-HCH are the main contributors to the POP mixture effect on adiposity. β-HCH and p,p'-DDE are associated with higher blood pressure in girls only.
Abstract Background Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. Methods This study included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (p,p′-Dichlorodiphenyldichloroethylene [p,p′-DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), percentage of fat mass, and blood pressure (mmHg) were measured at around 12 years of age. Single-exposure associations were studied using linear or logistic regressions, and the POP mixture effect was evaluated using quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and performed for boys and girls together and separately. Results Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These mixture effects were also statistically significant using BKMR. These associations were driven mainly by exposure to HCB and, to a lesser extent, to β-HCH. In addition, the single-exposure models showed an association between β-HCH and p,p′-DDE and higher systolic blood pressure, especially in girls (p,p′-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found for PCBs. Conclusion This study suggests that prenatal exposure to POPs, particularly organochlorine pesticides, remains associated with unfavorable cardiometabolic health up to the age of 12.
Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
Rouxel, Elke (author) / Costet, Nathalie (author) / Monfort, Christine (author) / Audouze, Karine (author) / Cirugeda, Lourdes (author) / Gaudreau, Eric (author) / Grimalt, Joan O. (author) / Ibarluzea, Jesus (author) / Lainé, Fabrice (author) / Llop, Sabrina (author)
2023-06-17
Article (Journal)
Electronic Resource
English