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External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications
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Highlights Human external and internal exposure to HFPOs were characterized near an FIP. Food and dust were the main human exposure pathways to PFASs near the FIP. External exposure of HFPOs was comparable but internal exposure was lower than PFOA. HFPO-DA exhibited much lower bioaccumulation potential than PFOA and HFPO-TA. HFPOs might be eliminated from human via urine faster than the PFCA counterparts.
Abstract Hexafluoropropylene oxide dimer and trimer acids (HFPO-DA and HFPO-TA) are used as alternatives to legacy perfluorooctanoic acid (PFOA); however, little is known about their human exposure risks. In this study, the concentrations of PFOA and HFPO were measured in major human exposure matrices and human bio-samples of local residents near a mega fluorochemical industrial park in Shandong, China, to characterize their external and internal exposures. Although HFPO-DA was detected in drinking water and indoor dust, it exhibited a considerably low bioaccumulation potential in animal-origin food and human samples (urine, hair, and serum), implying that it might be a benign alternative to PFOA. Although the estimated daily intake (EDI) of HFPO-TA was comparable to that of PFOA, its concentration in urine was higher than that of PFOA, implying that it might be eliminated faster than PFOA. A simple one-compartment pharmacokinetic model was applied to estimate the serum concentrations of the target compounds and subsequently compare them with the measured concentrations. The predicted concentration of PFOA in serum based on its concentration in urine and half-life was close to the measured value, confirming the distinct internal exposure of PFOA in the local residents. However, the measured concentrations of HFPO in serum were considerably lower than those predicted from the external EDI and urine concentrations, implying that they were eliminated faster than expected in humans. Various perfluoroalkyl substances were detected in human hair, and their compositions were similar to those in human serum, suggesting that hair is a good non-invasive indicator for long-term exposure to legacy long-chain perfluoroalkyl carboxylic acids and HFPOs. This study provided valuable information about the human exposure to legacy PFOA and HFPOs in highly impacted areas near point sources and necessitates studies on the toxicokinetics of HFPOs.
External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications
Graphical abstract Display Omitted
Highlights Human external and internal exposure to HFPOs were characterized near an FIP. Food and dust were the main human exposure pathways to PFASs near the FIP. External exposure of HFPOs was comparable but internal exposure was lower than PFOA. HFPO-DA exhibited much lower bioaccumulation potential than PFOA and HFPO-TA. HFPOs might be eliminated from human via urine faster than the PFCA counterparts.
Abstract Hexafluoropropylene oxide dimer and trimer acids (HFPO-DA and HFPO-TA) are used as alternatives to legacy perfluorooctanoic acid (PFOA); however, little is known about their human exposure risks. In this study, the concentrations of PFOA and HFPO were measured in major human exposure matrices and human bio-samples of local residents near a mega fluorochemical industrial park in Shandong, China, to characterize their external and internal exposures. Although HFPO-DA was detected in drinking water and indoor dust, it exhibited a considerably low bioaccumulation potential in animal-origin food and human samples (urine, hair, and serum), implying that it might be a benign alternative to PFOA. Although the estimated daily intake (EDI) of HFPO-TA was comparable to that of PFOA, its concentration in urine was higher than that of PFOA, implying that it might be eliminated faster than PFOA. A simple one-compartment pharmacokinetic model was applied to estimate the serum concentrations of the target compounds and subsequently compare them with the measured concentrations. The predicted concentration of PFOA in serum based on its concentration in urine and half-life was close to the measured value, confirming the distinct internal exposure of PFOA in the local residents. However, the measured concentrations of HFPO in serum were considerably lower than those predicted from the external EDI and urine concentrations, implying that they were eliminated faster than expected in humans. Various perfluoroalkyl substances were detected in human hair, and their compositions were similar to those in human serum, suggesting that hair is a good non-invasive indicator for long-term exposure to legacy long-chain perfluoroalkyl carboxylic acids and HFPOs. This study provided valuable information about the human exposure to legacy PFOA and HFPOs in highly impacted areas near point sources and necessitates studies on the toxicokinetics of HFPOs.
External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications
Feng, Xuemin (author) / Chen, Xin (author) / Yang, Yi (author) / Yang, Liping (author) / Zhu, Yumin (author) / Shan, Guoqiang (author) / Zhu, Lingyan (author) / Zhang, Shufeng (author)
2021-08-09
Article (Journal)
Electronic Resource
English