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Population attributable fraction of risk factors for low birth weight in the Japan Environment and Children’s Study
https://orcid.org/0000-0002-5233-2889
https://orcid.org/0000-0001-7772-0389
Highlights Population attributable fraction (PAF) for low birth weight was estimated for multiple factors. A total of 91,559 mother–child dyads were included in the study. The highest single PAF for low birth weight was inadequate gestational weight gain. The number of low birth weight can be reduced by 27% by preventing lead and tobacco exposure.
Abstract Background Low birth weight (LBW), which is considered a birth weight of <2500 g, poses significant health problems for children. However, population attributable fraction (PAF) of risk factors for LBW have not been well studied. Objective We aimed to re-evaluate associations between risk factors for LBW reported in previous studies that used the Japan Environment and Children’s Study (JECS) data, and to estimate the magnitude of risk using PAF. Methods Data including 91,559 mother–child dyads were obtained from JECS. Risk factors identified by previous studies that used JECS data were used to calculate odds ratios for LBW using a Bayesian logistic regression model. Based on calculated odds ratios, the PAF was calculated. Results Parity, history of adenomyosis, hypertension disorder of pregnancy, maternal age at birth, prepregnancy body mass index, gestational weight gain (GWG), maternal smoking and lead (Pb) exposure were all significantly associated with LBW. The sum of the PAF of all factors was 79.4 %, with the largest PAF among single risk factors being GWG (16.5 %); the environmental portion of the PAF (Pb exposure, 14.6 % + maternal smoking, 12.1 %) surpassed the PAF of GWG. Conclusion Our findings suggest that the number of births classified as LBW can be reduced by approximately 27% if Pb exposure is reduced to the lowest quartile and maternal smoking is eliminated. Further investigations are needed to identify unknown risk factors for LBW.
Population attributable fraction of risk factors for low birth weight in the Japan Environment and Children’s Study
https://orcid.org/0000-0002-5233-2889
https://orcid.org/0000-0001-7772-0389
Highlights Population attributable fraction (PAF) for low birth weight was estimated for multiple factors. A total of 91,559 mother–child dyads were included in the study. The highest single PAF for low birth weight was inadequate gestational weight gain. The number of low birth weight can be reduced by 27% by preventing lead and tobacco exposure.
Abstract Background Low birth weight (LBW), which is considered a birth weight of <2500 g, poses significant health problems for children. However, population attributable fraction (PAF) of risk factors for LBW have not been well studied. Objective We aimed to re-evaluate associations between risk factors for LBW reported in previous studies that used the Japan Environment and Children’s Study (JECS) data, and to estimate the magnitude of risk using PAF. Methods Data including 91,559 mother–child dyads were obtained from JECS. Risk factors identified by previous studies that used JECS data were used to calculate odds ratios for LBW using a Bayesian logistic regression model. Based on calculated odds ratios, the PAF was calculated. Results Parity, history of adenomyosis, hypertension disorder of pregnancy, maternal age at birth, prepregnancy body mass index, gestational weight gain (GWG), maternal smoking and lead (Pb) exposure were all significantly associated with LBW. The sum of the PAF of all factors was 79.4 %, with the largest PAF among single risk factors being GWG (16.5 %); the environmental portion of the PAF (Pb exposure, 14.6 % + maternal smoking, 12.1 %) surpassed the PAF of GWG. Conclusion Our findings suggest that the number of births classified as LBW can be reduced by approximately 27% if Pb exposure is reduced to the lowest quartile and maternal smoking is eliminated. Further investigations are needed to identify unknown risk factors for LBW.
Population attributable fraction of risk factors for low birth weight in the Japan Environment and Children’s Study
https://orcid.org/0000-0002-5233-2889
https://orcid.org/0000-0001-7772-0389
Highlights Population attributable fraction (PAF) for low birth weight was estimated for multiple factors. A total of 91,559 mother–child dyads were included in the study. The highest single PAF for low birth weight was inadequate gestational weight gain. The number of low birth weight can be reduced by 27% by preventing lead and tobacco exposure.
Abstract Background Low birth weight (LBW), which is considered a birth weight of <2500 g, poses significant health problems for children. However, population attributable fraction (PAF) of risk factors for LBW have not been well studied. Objective We aimed to re-evaluate associations between risk factors for LBW reported in previous studies that used the Japan Environment and Children’s Study (JECS) data, and to estimate the magnitude of risk using PAF. Methods Data including 91,559 mother–child dyads were obtained from JECS. Risk factors identified by previous studies that used JECS data were used to calculate odds ratios for LBW using a Bayesian logistic regression model. Based on calculated odds ratios, the PAF was calculated. Results Parity, history of adenomyosis, hypertension disorder of pregnancy, maternal age at birth, prepregnancy body mass index, gestational weight gain (GWG), maternal smoking and lead (Pb) exposure were all significantly associated with LBW. The sum of the PAF of all factors was 79.4 %, with the largest PAF among single risk factors being GWG (16.5 %); the environmental portion of the PAF (Pb exposure, 14.6 % + maternal smoking, 12.1 %) surpassed the PAF of GWG. Conclusion Our findings suggest that the number of births classified as LBW can be reduced by approximately 27% if Pb exposure is reduced to the lowest quartile and maternal smoking is eliminated. Further investigations are needed to identify unknown risk factors for LBW.
Population attributable fraction of risk factors for low birth weight in the Japan Environment and Children’s Study
Nishihama, Yukiko (author) / Nakayama, Shoji F. (author) / Tabuchi, Takahiro (author)
2022-10-02
Article (Journal)
Electronic Resource
English
Low birth weight , Risk factor , Population attributable fraction , The Japan Environment and Children’s Study , JECS , aOR , adjusted odds ratio , BMI , body mass index , CI , credible interval , GWG , gestational weight gain , HDP , hypertension disorder of pregnancy , Hg , mercury , ICC , intraclass correlation coefficient , the Japan Environment and Children’s Study , LBW , low birth weight , Mn , manganese , PAF , population attributable fraction , Pb , lead , PD , probability of direction , ROPE , region of practical equivalence , Se , selenium , T1 , first or second trimester , T2 , second or third trimester
Moisture and Lung Disease: Population-Attributable Risk Calculations
| British Library Conference Proceedings | 1997