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Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort
Abstract Rationale Previously we reported that airborne concentrations of cis-permethrin, but not trans-permethrin, measured during pregnancy in an inner city pediatric cohort was associated with cough by age 5. However, the effect of subsequent exposures to both permethrins during early childhood, and to piperonyl butoxide (PBO, a synergist for residential pyrethroid insecticides) remains to be elucidated. We hypothesized that prenatal and age 5–6year measures of PBO and permethrins would be associated with cough at age 5–6years in this cohort. Further, we explored the associations between these pesticide measures and wheeze, asthma, seroatopy, and fractional exhaled nitric oxide (FeNO). Methods PBO and permethrins were measured in personal air during the third trimester of pregnancy and indoor residential air at age 5–6years (n=224). Health outcome questionnaires were administered to the mothers of 5–6year old children. Indoor allergen specific and total immunoglobulin (Ig) E production was measured from sera collected at age 5, and FeNO was measured at 5–6years. The hypotheses were tested using regression models adjusting for common confounders. Results Noninfectious cough was reported among 14% of children at age 5–6years. Measures of prenatal PBO, but not age 5–6year PBO or permethrins, increased the odds of cough [OR (95% CI): 1.27 (1.09–1.48), p<0.01; n=217]. No significant associations were found for other measured health outcomes. Conclusions Prenatal PBO exposure was associated with childhood cough. It is unclear whether the observed effect is due mainly to PBO itself or residential pyrethroids of which PBO is an indicator.
Highlights ► The health impact of residential pyrethroid exposure has not been evaluated fully. ► We examined permethrin and a common pyrethroid synergist piperonyl butoxide (PBO). ► Permethrin and PBO were measured in air samples prenatally and at age 5–6years. ► Exposure to prenatal PBO only was associated with increased odds of cough. ► In utero exposure to PBO or pyrethroids may lead to cough in early childhood.
Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort
Abstract Rationale Previously we reported that airborne concentrations of cis-permethrin, but not trans-permethrin, measured during pregnancy in an inner city pediatric cohort was associated with cough by age 5. However, the effect of subsequent exposures to both permethrins during early childhood, and to piperonyl butoxide (PBO, a synergist for residential pyrethroid insecticides) remains to be elucidated. We hypothesized that prenatal and age 5–6year measures of PBO and permethrins would be associated with cough at age 5–6years in this cohort. Further, we explored the associations between these pesticide measures and wheeze, asthma, seroatopy, and fractional exhaled nitric oxide (FeNO). Methods PBO and permethrins were measured in personal air during the third trimester of pregnancy and indoor residential air at age 5–6years (n=224). Health outcome questionnaires were administered to the mothers of 5–6year old children. Indoor allergen specific and total immunoglobulin (Ig) E production was measured from sera collected at age 5, and FeNO was measured at 5–6years. The hypotheses were tested using regression models adjusting for common confounders. Results Noninfectious cough was reported among 14% of children at age 5–6years. Measures of prenatal PBO, but not age 5–6year PBO or permethrins, increased the odds of cough [OR (95% CI): 1.27 (1.09–1.48), p<0.01; n=217]. No significant associations were found for other measured health outcomes. Conclusions Prenatal PBO exposure was associated with childhood cough. It is unclear whether the observed effect is due mainly to PBO itself or residential pyrethroids of which PBO is an indicator.
Highlights ► The health impact of residential pyrethroid exposure has not been evaluated fully. ► We examined permethrin and a common pyrethroid synergist piperonyl butoxide (PBO). ► Permethrin and PBO were measured in air samples prenatally and at age 5–6years. ► Exposure to prenatal PBO only was associated with increased odds of cough. ► In utero exposure to PBO or pyrethroids may lead to cough in early childhood.
Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort
Liu, Bian (author) / Jung, Kyung Hwa (author) / Horton, Megan K. (author) / Camann, David E. (author) / Liu, Xinhua (author) / Reardon, Ann Marie (author) / Perzanowski, Matthew S. (author) / Zhang, Hanjie (author) / Perera, Frederica P. (author) / Whyatt, Robin M. (author)
Environmental International ; 48 ; 156-161
2012-07-30
6 pages
Article (Journal)
Electronic Resource
English
CCCEH , Columbia Center for Children's Environmental Health , CI , 95% confidence interval , ETS , environmental tobacco smoke , FeNO , fractional exhaled nitric oxide , IgE , immunoglobulin E , LOD , limit of detection , OR , odds ratio , PBO , piperonyl butoxide , Prenatal pesticide exposure , Cough , Piperonyl butoxide , Permethrin
Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort
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