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Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy
Abstract Background Previous research has linked polybrominated diphenyl ether (PBDE) exposure to poor birth outcomes and altered thyroid hormone levels. Objectives We examined whether maternal PBDE serum levels were associated with infant birth weight (g), head circumference (cm), birth length (cm), and birth weight percentile for gestational age. We explored the potential for a mediating role of thyroid hormone levels. Methods During 2008–2010, we recruited 140 pregnant women in their third trimester as part of a larger clinical obstetrics study known as Healthy Pregnancy, Healthy Baby. Blood samples were collected during a routine prenatal clinic visit. Serum was analyzed for PBDEs, phenolic metabolites, and thyroid hormones. Birth outcome information was abstracted from medical records. Results In unadjusted models, a two-fold increase in maternal BDE 153 was associated with an average decrease in head circumference of 0.32cm (95% CI: −0.53, −0.12); however, this association was attenuated after control for maternal risk factors. BDE 47 and 99 were similarly negatively associated but with 95% confidence intervals crossing the null. Associations were unchanged in the presence of thyroid hormones. Conclusions Our data suggest a potential deleterious association between maternal PBDE levels and infant head circumference; however, confirmatory studies are needed in larger sample sizes. A mediating role of thyroid hormones was not apparent.
Highlights Maternal PBDE serum levels may be associated with decreased infant head circumference. Other examined birth outcomes were not associated with PBDE exposure. Maternal thyroid hormone levels did not appear to play a mediating role.
Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy
Abstract Background Previous research has linked polybrominated diphenyl ether (PBDE) exposure to poor birth outcomes and altered thyroid hormone levels. Objectives We examined whether maternal PBDE serum levels were associated with infant birth weight (g), head circumference (cm), birth length (cm), and birth weight percentile for gestational age. We explored the potential for a mediating role of thyroid hormone levels. Methods During 2008–2010, we recruited 140 pregnant women in their third trimester as part of a larger clinical obstetrics study known as Healthy Pregnancy, Healthy Baby. Blood samples were collected during a routine prenatal clinic visit. Serum was analyzed for PBDEs, phenolic metabolites, and thyroid hormones. Birth outcome information was abstracted from medical records. Results In unadjusted models, a two-fold increase in maternal BDE 153 was associated with an average decrease in head circumference of 0.32cm (95% CI: −0.53, −0.12); however, this association was attenuated after control for maternal risk factors. BDE 47 and 99 were similarly negatively associated but with 95% confidence intervals crossing the null. Associations were unchanged in the presence of thyroid hormones. Conclusions Our data suggest a potential deleterious association between maternal PBDE levels and infant head circumference; however, confirmatory studies are needed in larger sample sizes. A mediating role of thyroid hormones was not apparent.
Highlights Maternal PBDE serum levels may be associated with decreased infant head circumference. Other examined birth outcomes were not associated with PBDE exposure. Maternal thyroid hormone levels did not appear to play a mediating role.
Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy
Miranda, Marie Lynn (author) / Anthopolos, Rebecca (author) / Wolkin, Amy (author) / Stapleton, Heather M. (author)
Environmental International ; 85 ; 244-253
2015-09-11
10 pages
Article (Journal)
Electronic Resource
English
BMI , body mass index , FT4 , free thyroxine , FT3 , free triiodothyronine , HPHB , Healthy Pregnancy, Healthy Baby , PBDE , polybrominated diphenyl ether , OH-BDE , polybrominated diphenyl ether metabolite , TSH , thyroid stimulating hormone , T4 , thyroxine , TT4 , total thyroxine , TT3 , total triiodothyronine , T3 , triiodothyronine , Birth outcomes , Birth weight , Head circumference , Infant length , Polybrominated diphenyl ethers , Thyroid hormone
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