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Boron exposure through drinking water during pregnancy and birth size
https://orcid.org/0000-0002-0362-579X
Abstract Background Boron is a metalloid found at highly varying concentrations in soil and water. Experimental data indicate that boron is a developmental toxicant, but the few human toxicity data available concern mostly male reproduction. Objectives To evaluate potential effects of boron exposure through drinking water on pregnancy outcomes. Methods In a mother-child cohort in northern Argentina (n =194), 1–3 samples of serum, whole blood and urine were collected per woman during pregnancy and analyzed for boron and other elements to which exposure occurred, using inductively coupled plasma mass spectrometry. Infant weight, length and head circumference were measured at birth. Results Drinking water boron ranged 377–10,929μg/L. The serum boron concentrations during pregnancy ranged 0.73–605μg/L (median 133μg/L) and correlated strongly with whole-blood and urinary boron, and, to a lesser extent, with water boron. In multivariable-adjusted linear spline regression analysis (non-linear association), we found that serum boron concentrations above 80μg/L were inversely associated with birth length (B−0.69cm, 95% CI −1.4; −0.024, p =0.043, per 100μg/L increase in serum boron). The impact of boron appeared stronger when we restricted the exposure to the third trimester, when the serum boron concentrations were the highest (0.73–447μg/L). An increase in serum boron of 100μg/L in the third trimester corresponded to 0.9cm shorter and 120g lighter newborns (p =0.001 and 0.021, respectively). Conclusions Considering that elevated boron concentrations in drinking water are common in many areas of the world, although more screening is warranted, our novel findings warrant additional research on early-life exposure in other populations.
Highlights Elevated water boron levels appear common worldwide but more screening is warranted. Boron has been suggested to be a developmental toxicant but human data is scarce. We studied a mother-child cohort exposed to water boron (0.4–10mg/L) in Argentina. Serum boron >80μg/L was inversely associated with birth length and weight. A 100μg/L increase in serum boron was associated with 120g lighter newborns.
Boron exposure through drinking water during pregnancy and birth size
https://orcid.org/0000-0002-0362-579X
Abstract Background Boron is a metalloid found at highly varying concentrations in soil and water. Experimental data indicate that boron is a developmental toxicant, but the few human toxicity data available concern mostly male reproduction. Objectives To evaluate potential effects of boron exposure through drinking water on pregnancy outcomes. Methods In a mother-child cohort in northern Argentina (n =194), 1–3 samples of serum, whole blood and urine were collected per woman during pregnancy and analyzed for boron and other elements to which exposure occurred, using inductively coupled plasma mass spectrometry. Infant weight, length and head circumference were measured at birth. Results Drinking water boron ranged 377–10,929μg/L. The serum boron concentrations during pregnancy ranged 0.73–605μg/L (median 133μg/L) and correlated strongly with whole-blood and urinary boron, and, to a lesser extent, with water boron. In multivariable-adjusted linear spline regression analysis (non-linear association), we found that serum boron concentrations above 80μg/L were inversely associated with birth length (B−0.69cm, 95% CI −1.4; −0.024, p =0.043, per 100μg/L increase in serum boron). The impact of boron appeared stronger when we restricted the exposure to the third trimester, when the serum boron concentrations were the highest (0.73–447μg/L). An increase in serum boron of 100μg/L in the third trimester corresponded to 0.9cm shorter and 120g lighter newborns (p =0.001 and 0.021, respectively). Conclusions Considering that elevated boron concentrations in drinking water are common in many areas of the world, although more screening is warranted, our novel findings warrant additional research on early-life exposure in other populations.
Highlights Elevated water boron levels appear common worldwide but more screening is warranted. Boron has been suggested to be a developmental toxicant but human data is scarce. We studied a mother-child cohort exposed to water boron (0.4–10mg/L) in Argentina. Serum boron >80μg/L was inversely associated with birth length and weight. A 100μg/L increase in serum boron was associated with 120g lighter newborns.
Boron exposure through drinking water during pregnancy and birth size
https://orcid.org/0000-0002-0362-579X
Abstract Background Boron is a metalloid found at highly varying concentrations in soil and water. Experimental data indicate that boron is a developmental toxicant, but the few human toxicity data available concern mostly male reproduction. Objectives To evaluate potential effects of boron exposure through drinking water on pregnancy outcomes. Methods In a mother-child cohort in northern Argentina (n =194), 1–3 samples of serum, whole blood and urine were collected per woman during pregnancy and analyzed for boron and other elements to which exposure occurred, using inductively coupled plasma mass spectrometry. Infant weight, length and head circumference were measured at birth. Results Drinking water boron ranged 377–10,929μg/L. The serum boron concentrations during pregnancy ranged 0.73–605μg/L (median 133μg/L) and correlated strongly with whole-blood and urinary boron, and, to a lesser extent, with water boron. In multivariable-adjusted linear spline regression analysis (non-linear association), we found that serum boron concentrations above 80μg/L were inversely associated with birth length (B−0.69cm, 95% CI −1.4; −0.024, p =0.043, per 100μg/L increase in serum boron). The impact of boron appeared stronger when we restricted the exposure to the third trimester, when the serum boron concentrations were the highest (0.73–447μg/L). An increase in serum boron of 100μg/L in the third trimester corresponded to 0.9cm shorter and 120g lighter newborns (p =0.001 and 0.021, respectively). Conclusions Considering that elevated boron concentrations in drinking water are common in many areas of the world, although more screening is warranted, our novel findings warrant additional research on early-life exposure in other populations.
Highlights Elevated water boron levels appear common worldwide but more screening is warranted. Boron has been suggested to be a developmental toxicant but human data is scarce. We studied a mother-child cohort exposed to water boron (0.4–10mg/L) in Argentina. Serum boron >80μg/L was inversely associated with birth length and weight. A 100μg/L increase in serum boron was associated with 120g lighter newborns.
Boron exposure through drinking water during pregnancy and birth size
Igra, Annachiara Malin (author) / Harari, Florencia (author) / Lu, Ying (author) / Casimiro, Esperanza (author) / Vahter, Marie (author)
Environmental International ; 95 ; 54-60
2016-07-28
7 pages
Article (Journal)
Electronic Resource
English
Boron exposure through drinking water during pregnancy and birth size
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