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A platform for research: civil engineering, architecture and urbanism
Exposure to pesticides and diabetes: A systematic review and meta-analysis
Abstract Background Diabetes mellitus has a multifactorial pathogenesis with a strong genetic component as well as many environmental and lifestyle influences. Emerging evidence suggests that environmental contaminants, including pesticides, might play an important role in the pathogenesis of diabetes. Objectives We performed a systematic review and meta-analysis of observational studies that assessed the association between exposure to pesticides and diabetes and we examined the presence of heterogeneity and biases across available studies. Methods A comprehensive literature search of peer-reviewed original research pertaining to pesticide exposure and diabetes, published until 30st May 2015, with no language restriction, was conducted. Eligible studies were those that investigated potential associations between pesticides and diabetes without restrictions on diabetes type. We included cohort studies, case–control studies and cross-sectional studies. We extracted information on study characteristics, type of pesticide assessed, exposure assessment, outcome definition, effect estimate and sample size. Results We identified 22 studies assessing the association between pesticides and diabetes. The summary OR for the association of top vs. bottom tertile of exposure to any type of pesticide and diabetes was 1.58 (95% CI: 1.32–1.90, p =1.21×10−6), with large heterogeneity (I2 =66.8%). Studies evaluating Type 2 diabetes in particular (n =13 studies), showed a similar summary effect comparing top vs. bottom tertiles of exposure: 1.61 (95% CI 1.37–1.88, p =3.51×10−9) with no heterogeneity (I2 =0%). Analysis by type of pesticide yielded an increased risk of diabetes for DDE, heptachlor, HCB, DDT, and trans-nonachlor or chlordane. Conclusions The epidemiological evidence, supported by mechanistic studies, suggests an association between exposure to organochlorine pesticides and Type 2 diabetes.
Highlights A systematic review identified 22 studies on pesticides and type 2 diabetes Data suggests an association between organochlorine exposure and type 2 diabetes DDE, heptachlor, HCB, DDT, and trans-nonachlor show similar associations with type 2 diabetes Mechanistic studies support a link between organochlorines and insulin resistance
Exposure to pesticides and diabetes: A systematic review and meta-analysis
Abstract Background Diabetes mellitus has a multifactorial pathogenesis with a strong genetic component as well as many environmental and lifestyle influences. Emerging evidence suggests that environmental contaminants, including pesticides, might play an important role in the pathogenesis of diabetes. Objectives We performed a systematic review and meta-analysis of observational studies that assessed the association between exposure to pesticides and diabetes and we examined the presence of heterogeneity and biases across available studies. Methods A comprehensive literature search of peer-reviewed original research pertaining to pesticide exposure and diabetes, published until 30st May 2015, with no language restriction, was conducted. Eligible studies were those that investigated potential associations between pesticides and diabetes without restrictions on diabetes type. We included cohort studies, case–control studies and cross-sectional studies. We extracted information on study characteristics, type of pesticide assessed, exposure assessment, outcome definition, effect estimate and sample size. Results We identified 22 studies assessing the association between pesticides and diabetes. The summary OR for the association of top vs. bottom tertile of exposure to any type of pesticide and diabetes was 1.58 (95% CI: 1.32–1.90, p =1.21×10−6), with large heterogeneity (I2 =66.8%). Studies evaluating Type 2 diabetes in particular (n =13 studies), showed a similar summary effect comparing top vs. bottom tertiles of exposure: 1.61 (95% CI 1.37–1.88, p =3.51×10−9) with no heterogeneity (I2 =0%). Analysis by type of pesticide yielded an increased risk of diabetes for DDE, heptachlor, HCB, DDT, and trans-nonachlor or chlordane. Conclusions The epidemiological evidence, supported by mechanistic studies, suggests an association between exposure to organochlorine pesticides and Type 2 diabetes.
Highlights A systematic review identified 22 studies on pesticides and type 2 diabetes Data suggests an association between organochlorine exposure and type 2 diabetes DDE, heptachlor, HCB, DDT, and trans-nonachlor show similar associations with type 2 diabetes Mechanistic studies support a link between organochlorines and insulin resistance
Exposure to pesticides and diabetes: A systematic review and meta-analysis
Evangelou, Evangelos (author) / Ntritsos, Georgios (author) / Chondrogiorgi, Maria (author) / Kavvoura, Fotini K. (author) / Hernández, Antonio F. (author) / Ntzani, Evangelia E. (author) / Tzoulaki, Ioanna (author)
Environmental International ; 91 ; 60-68
2016-02-08
9 pages
Article (Journal)
Electronic Resource
English
Exposure to pesticides and diabetes: A systematic review and meta-analysis
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