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Investigation of natural minerals for ulcerative colitis therapy
https://orcid.org/0000-0003-0391-7159
https://orcid.org/0000-0002-3097-2850
Abstract Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy.
Graphical abstract Display Omitted
Highlights Five natural minerals for ulcerative colitis (UC) therapy were in vivo evaluated. Natural minerals exhibited different therapeutic efficiency on ulcerative colitis. Microflora in UC mice colon could be altered toward balance by clay minerals.
Investigation of natural minerals for ulcerative colitis therapy
https://orcid.org/0000-0003-0391-7159
https://orcid.org/0000-0002-3097-2850
Abstract Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy.
Graphical abstract Display Omitted
Highlights Five natural minerals for ulcerative colitis (UC) therapy were in vivo evaluated. Natural minerals exhibited different therapeutic efficiency on ulcerative colitis. Microflora in UC mice colon could be altered toward balance by clay minerals.
Investigation of natural minerals for ulcerative colitis therapy
https://orcid.org/0000-0003-0391-7159
https://orcid.org/0000-0002-3097-2850
Abstract Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy.
Graphical abstract Display Omitted
Highlights Five natural minerals for ulcerative colitis (UC) therapy were in vivo evaluated. Natural minerals exhibited different therapeutic efficiency on ulcerative colitis. Microflora in UC mice colon could be altered toward balance by clay minerals.
Investigation of natural minerals for ulcerative colitis therapy
Sun, Zhiya (author) / Long, Mei (author) / Liu, Xinxuan (author) / Zhang, Yi (author) / Li, Shunxiang (author) / Bai, Limei (author) / Yang, Huaming (author)
Applied Clay Science ; 186
2020-01-02
Article (Journal)
Electronic Resource
English
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