A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Residential greenness-related DNA methylation changes
https://orcid.org/0000-0003-1542-0756
https://orcid.org/0000-0002-6309-6439
https://orcid.org/0000-0001-9998-0464
Graphical abstract Display Omitted
Highlights DNA methylation in blood captures residential greenness in the population-representative Swiss samples. Residential greenness-related DNA methylation profiles are compared with candidate pathways curated from public databases of previously published EWAS results. Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to greenness in the immediate surrounding may be more health-relevant than in the neighborhood.
Abstract Background Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.
Residential greenness-related DNA methylation changes
https://orcid.org/0000-0003-1542-0756
https://orcid.org/0000-0002-6309-6439
https://orcid.org/0000-0001-9998-0464
Graphical abstract Display Omitted
Highlights DNA methylation in blood captures residential greenness in the population-representative Swiss samples. Residential greenness-related DNA methylation profiles are compared with candidate pathways curated from public databases of previously published EWAS results. Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to greenness in the immediate surrounding may be more health-relevant than in the neighborhood.
Abstract Background Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.
Residential greenness-related DNA methylation changes
https://orcid.org/0000-0003-1542-0756
https://orcid.org/0000-0002-6309-6439
https://orcid.org/0000-0001-9998-0464
Graphical abstract Display Omitted
Highlights DNA methylation in blood captures residential greenness in the population-representative Swiss samples. Residential greenness-related DNA methylation profiles are compared with candidate pathways curated from public databases of previously published EWAS results. Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to greenness in the immediate surrounding may be more health-relevant than in the neighborhood.
Abstract Background Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.
Residential greenness-related DNA methylation changes
Jeong, Ayoung (author) / Eze, Ikenna C. (author) / Vienneau, Danielle (author) / de Hoogh, Kees (author) / Keidel, Dirk (author) / Rothe, Thomas (author) / Burdet, Luc (author) / Holloway, John W. (author) / Jarvis, Debbie (author) / Kronenberg, Florian (author)
2021-10-18
Article (Journal)
Electronic Resource
English
Residential surrounding greenness and DNA methylation: An epigenome-wide association study
| Elsevier | 2021
Residential surrounding greenness and DNA methylation: An epigenome-wide association study
| DOAJ | 2021