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SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF
A method is provided for indicating whether a human has an increased risk for a myocardial infarction (MI), or whether a human's risk for MI is reduced by treatment with an HMG-CoA reductase inhibitor, e.g. a statin such as pravastatin, atorvastatin, simvastatin, cerevastatin, or lovastatin. The method comprises testing nucleic acid from the human for presence or absence of a single nucleotide polymorphism at position 101 of SEQ ID NO:190 or its complement. Presence of G at position 101 of SEQ ID NO:190 or C at position 101 of the complement indicates that the human has increased risk for MI and that the risk is reduced by such treatment. Also provided are polynucleotides useful for such testing.
SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF
A method is provided for indicating whether a human has an increased risk for a myocardial infarction (MI), or whether a human's risk for MI is reduced by treatment with an HMG-CoA reductase inhibitor, e.g. a statin such as pravastatin, atorvastatin, simvastatin, cerevastatin, or lovastatin. The method comprises testing nucleic acid from the human for presence or absence of a single nucleotide polymorphism at position 101 of SEQ ID NO:190 or its complement. Presence of G at position 101 of SEQ ID NO:190 or C at position 101 of the complement indicates that the human has increased risk for MI and that the risk is reduced by such treatment. Also provided are polynucleotides useful for such testing.
SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF
POLYMORPHISMES NUCLEOTIDES SIMPLES ASSOCIES A DES TROUBLES CARDIOVASCULAIRES ET A UNE REPONSE AU MEDICAMENT, LEURS PROCEDES DE DETECTION ET D'UTILISATION
CARGILL MICHELE (author) / IAKOUBOVA OLGA (author) / DEVLIN JAMES J (author) / TSUCHIHASHI ZENTA (author) / SHAW PETER (author) / PLOUGHMAN LYNN MARIE (author) / ZERBA KIM E (author) / KOUSTUBH RANADE (author) / KIRCHGESSNER TODD (author)
2015-06-23
Patent
Electronic Resource
English
IPC:
C12Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
,
Mess- oder Untersuchungsverfahren unter Einbeziehung von Enzymen, Nukleinsäuren oder Mikroorganismen
/
A61K
Zubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke
,
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
/
C04B
Kalk
,
LIME
/
C07H
Zucker
,
SUGARS
/
C40B
Kombinatorische Chemie
,
COMBINATORIAL CHEMISTRY
/
G01N
Untersuchen oder Analysieren von Stoffen durch Bestimmen ihrer chemischen oder physikalischen Eigenschaften
,
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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