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Preparation method of loofah sponge-imitated inner collateral bone scaffold
The invention discloses a preparation method of a loofah sponge-imitated inner collateral bone scaffold, and belongs to the technical field of bone tissue engineering, and the preparation method comprises the following steps: acquiring original data of a loofah sponge inner collateral geometric structure in nature through micro-CT (Computed Tomography) scanning; performing de-noising processing on original data obtained through scanning, andreconstructing a three-dimensional model which is equal to the loofah sponge inner complex structure in proportion; designing and parameterizing the three-dimensional model through Magics software, and constructing a three-dimensional bone scaffold model which has a complex porous structure and is suitable for a photocuring three-dimensional forming process; by utilizing a photocuring three-dimensional forming principle, preparing a loofah sponge-imitated inner collateral bone scaffold object by taking biological ceramics as a raw material; and through degreasing and sintering post-treatment, obtaining the complex porous bionic bone scaffold of which the porosity and the pore diameter are both in a range suitable for cell ingrowth. The prepared loofah sponge-imitated inner collateral bone scaffold can be used for implanting critical bone defects of rabbit parietal bones and can play a role in supporting and protecting bone defects, and bone cells can grow into the porous scaffold along with the increase of implantation time.
本发明公开了一种仿丝瓜瓤内络骨支架的制备方法，属于骨组织工程技术领域，其包括以下步骤：通过micro‑CT扫描获取自然界中丝瓜瓤内络几何结构的原始数据；对扫描得到的原始数据进行去噪处理，并重构出与丝瓜瓤内络结构等比例的三维模型；将三维模型通过Magics软件设计参数化，构建具有复杂多孔结构且适于光固化立体成形工艺的三维骨支架模型；利用光固化立体成形原理，以生物陶瓷为原料制备出仿丝瓜瓤内络骨支架实物；通过脱脂、烧结后处理，获得孔隙率和孔径均在适合细胞长入范围内的复杂多孔仿生骨支架。本发明制备的仿丝瓜瓤内络骨支架可用于兔顶骨临界骨缺损植入，可以起到支撑和保护骨缺损的作用，随着植入时间的增加，骨细胞可长入多孔支架内部。
Preparation method of loofah sponge-imitated inner collateral bone scaffold
The invention discloses a preparation method of a loofah sponge-imitated inner collateral bone scaffold, and belongs to the technical field of bone tissue engineering, and the preparation method comprises the following steps: acquiring original data of a loofah sponge inner collateral geometric structure in nature through micro-CT (Computed Tomography) scanning; performing de-noising processing on original data obtained through scanning, andreconstructing a three-dimensional model which is equal to the loofah sponge inner complex structure in proportion; designing and parameterizing the three-dimensional model through Magics software, and constructing a three-dimensional bone scaffold model which has a complex porous structure and is suitable for a photocuring three-dimensional forming process; by utilizing a photocuring three-dimensional forming principle, preparing a loofah sponge-imitated inner collateral bone scaffold object by taking biological ceramics as a raw material; and through degreasing and sintering post-treatment, obtaining the complex porous bionic bone scaffold of which the porosity and the pore diameter are both in a range suitable for cell ingrowth. The prepared loofah sponge-imitated inner collateral bone scaffold can be used for implanting critical bone defects of rabbit parietal bones and can play a role in supporting and protecting bone defects, and bone cells can grow into the porous scaffold along with the increase of implantation time.
本发明公开了一种仿丝瓜瓤内络骨支架的制备方法，属于骨组织工程技术领域，其包括以下步骤：通过micro‑CT扫描获取自然界中丝瓜瓤内络几何结构的原始数据；对扫描得到的原始数据进行去噪处理，并重构出与丝瓜瓤内络结构等比例的三维模型；将三维模型通过Magics软件设计参数化，构建具有复杂多孔结构且适于光固化立体成形工艺的三维骨支架模型；利用光固化立体成形原理，以生物陶瓷为原料制备出仿丝瓜瓤内络骨支架实物；通过脱脂、烧结后处理，获得孔隙率和孔径均在适合细胞长入范围内的复杂多孔仿生骨支架。本发明制备的仿丝瓜瓤内络骨支架可用于兔顶骨临界骨缺损植入，可以起到支撑和保护骨缺损的作用，随着植入时间的增加，骨细胞可长入多孔支架内部。
Preparation method of loofah sponge-imitated inner collateral bone scaffold
一种仿丝瓜瓤内络骨支架的制备方法
ZOU BIN (author) / CHEN QINGHUA (author) / LAI QINGGUO (author) / XING HONGYU (author) / LIU XIAOYAN (author) / CHANG JINGJING (author)
2021-05-18
Patent
Electronic Resource
Chinese
IPC:
C04B
Kalk
,
LIME
/
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
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