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Porous calcium-magnesium dual-phase ceramic microsphere and preparation method thereof
The invention discloses a porous calcium-magnesium dual-phase ceramic microsphere and a preparation method thereof. Calcium phosphate and magnesium phosphate are used as main raw materials, a water-in-oil type emulsification cross-linking method is used for preparing the porous calcium-magnesium dual-phase ceramic microsphere, and the porous calcium-magnesium dual-phase ceramic microsphere is loaded with antibacterial, anti-tumor, anti-osteoporosis or osteogenesis-promoting drugs and the like. The obtained microsphere has uniform particle size distribution, the porous structure of the microsphere can ensure a large drug loading rate, meanwhile, the microsphere has continuous calcium ion and magnesium ion release capacity, good biocompatibility, good bone growth induction performance and good blood vessel growth induction performance, and the dual-phase ceramic microsphere can continuously release drugs and play a role, and can be used for drug delivery and bone filling.
本发明公开了一种多孔钙镁双相陶瓷微球及其制备方法。以磷酸钙盐和磷酸镁盐为主要原料，利用油包水型乳化交联法制备多孔钙镁双相陶瓷微球，并负载抗菌、抗肿瘤、抗骨质疏松或促成骨等药物。所得微球具有较为均匀的粒径分布，且其多孔结构可确保较大的药物装载率，同时具有持续的钙离子和镁离子释放能力、良好的生物相容性、良好的诱导骨生长性，良好的诱导血管生长性，且该双相陶瓷微球可持续性释放药物并发挥作用，可用于药物递送及骨填充。
Porous calcium-magnesium dual-phase ceramic microsphere and preparation method thereof
The invention discloses a porous calcium-magnesium dual-phase ceramic microsphere and a preparation method thereof. Calcium phosphate and magnesium phosphate are used as main raw materials, a water-in-oil type emulsification cross-linking method is used for preparing the porous calcium-magnesium dual-phase ceramic microsphere, and the porous calcium-magnesium dual-phase ceramic microsphere is loaded with antibacterial, anti-tumor, anti-osteoporosis or osteogenesis-promoting drugs and the like. The obtained microsphere has uniform particle size distribution, the porous structure of the microsphere can ensure a large drug loading rate, meanwhile, the microsphere has continuous calcium ion and magnesium ion release capacity, good biocompatibility, good bone growth induction performance and good blood vessel growth induction performance, and the dual-phase ceramic microsphere can continuously release drugs and play a role, and can be used for drug delivery and bone filling.
本发明公开了一种多孔钙镁双相陶瓷微球及其制备方法。以磷酸钙盐和磷酸镁盐为主要原料，利用油包水型乳化交联法制备多孔钙镁双相陶瓷微球，并负载抗菌、抗肿瘤、抗骨质疏松或促成骨等药物。所得微球具有较为均匀的粒径分布，且其多孔结构可确保较大的药物装载率，同时具有持续的钙离子和镁离子释放能力、良好的生物相容性、良好的诱导骨生长性，良好的诱导血管生长性，且该双相陶瓷微球可持续性释放药物并发挥作用，可用于药物递送及骨填充。
Porous calcium-magnesium dual-phase ceramic microsphere and preparation method thereof
一种多孔钙镁双相陶瓷微球及其制备方法
DAI HONGLIAN (author) / HOU WEN (author) / SHU DAN (author) / HUANG JIALONG (author) / ZHANG YUXI (author)
2021-06-04
Patent
Electronic Resource
Chinese
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