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Calcium hexaluminate ceramic with biological activity and preparation method thereof
The invention discloses calcium hexaluminate ceramic with biological activity and a preparation method of the calcium hexaluminate ceramic. The method comprises the following steps: mixing aluminum oxide powder and calcium hydroxide powder to obtain mixed powder, adding the mixed powder into a polyvinyl alcohol solution, uniformly mixing to obtain a mixture, carrying out compression molding and sintering treatment to obtain the calcium hexaluminate ceramic, and soaking the calcium hexaluminate ceramic in simulated human body fluid in a shaking state, taking the ceramic out, washing and drying to obtain the calcium hexaluminate ceramic with biological activity. The cell osteogenic differentiation promoting effect of the calcium hexaluminate ceramic with biological activity is superior to that of pure calcium hexaluminate ceramic. According to the invention, while the calcium hexaluminate ceramic is prepared, the bioactive substance hydroxyapatite is deposited on the surface of the calcium hexaluminate ceramic by soaking the calcium hexaluminate ceramic in the simulated body fluid. The method is simple to operate and simple in preparation process, and the osteogenesis promoting performance of the calcium hexaluminate ceramic is also improved while the biological activity of the calcium hexaluminate ceramic is improved; the calcium hexaluminate ceramic with biological activity has certain practical value for expanding the application of the calcium hexaluminate ceramic in the field of bone repair medical materials.
本发明公开了一种具有生物活性的六铝酸钙陶瓷及其制备方法。该方法包括：将氧化铝粉末和氢氧化钙粉末混合，得到混合粉体，将混合粉体加入聚乙烯醇溶液中，混匀，得到混合物，压制成型，烧结处理，得到六铝酸钙陶瓷；在摇动状态下将六铝酸钙陶瓷浸泡在人体模拟体液中，取出，洗涤，烘干，得到具有生物活性的六铝酸钙陶瓷。其促细胞成骨分化效果优于纯的六铝酸钙陶瓷。本发明制备六铝酸钙陶瓷的同时通过浸泡模拟体液的方式在六铝酸钙陶瓷表面沉积了生物活性物质羟基磷灰石，该方法操作简易，制备过程简单，在提高六铝酸钙陶瓷生物活性的同时还提高了六铝酸钙陶瓷的促成骨性能，对拓展六铝酸钙陶瓷在骨修复医用材料领域的应用具有一定的实用价值。
Calcium hexaluminate ceramic with biological activity and preparation method thereof
The invention discloses calcium hexaluminate ceramic with biological activity and a preparation method of the calcium hexaluminate ceramic. The method comprises the following steps: mixing aluminum oxide powder and calcium hydroxide powder to obtain mixed powder, adding the mixed powder into a polyvinyl alcohol solution, uniformly mixing to obtain a mixture, carrying out compression molding and sintering treatment to obtain the calcium hexaluminate ceramic, and soaking the calcium hexaluminate ceramic in simulated human body fluid in a shaking state, taking the ceramic out, washing and drying to obtain the calcium hexaluminate ceramic with biological activity. The cell osteogenic differentiation promoting effect of the calcium hexaluminate ceramic with biological activity is superior to that of pure calcium hexaluminate ceramic. According to the invention, while the calcium hexaluminate ceramic is prepared, the bioactive substance hydroxyapatite is deposited on the surface of the calcium hexaluminate ceramic by soaking the calcium hexaluminate ceramic in the simulated body fluid. The method is simple to operate and simple in preparation process, and the osteogenesis promoting performance of the calcium hexaluminate ceramic is also improved while the biological activity of the calcium hexaluminate ceramic is improved; the calcium hexaluminate ceramic with biological activity has certain practical value for expanding the application of the calcium hexaluminate ceramic in the field of bone repair medical materials.
本发明公开了一种具有生物活性的六铝酸钙陶瓷及其制备方法。该方法包括：将氧化铝粉末和氢氧化钙粉末混合，得到混合粉体，将混合粉体加入聚乙烯醇溶液中，混匀，得到混合物，压制成型，烧结处理，得到六铝酸钙陶瓷；在摇动状态下将六铝酸钙陶瓷浸泡在人体模拟体液中，取出，洗涤，烘干，得到具有生物活性的六铝酸钙陶瓷。其促细胞成骨分化效果优于纯的六铝酸钙陶瓷。本发明制备六铝酸钙陶瓷的同时通过浸泡模拟体液的方式在六铝酸钙陶瓷表面沉积了生物活性物质羟基磷灰石，该方法操作简易，制备过程简单，在提高六铝酸钙陶瓷生物活性的同时还提高了六铝酸钙陶瓷的促成骨性能，对拓展六铝酸钙陶瓷在骨修复医用材料领域的应用具有一定的实用价值。
Calcium hexaluminate ceramic with biological activity and preparation method thereof
一种具有生物活性的六铝酸钙陶瓷及其制备方法
YE JIANDONG (author) / LIANG CAIXIA (author)
2021-09-03
Patent
Electronic Resource
Chinese
IPC:
C04B
Kalk
,
LIME
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