A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Synthetic method of o-trifluoromethyl benzoyl chloride
The invention discloses a synthesis method of o-trifluoromethyl benzoyl chloride, o-xylene is used as a starting raw material, the o-trifluoromethyl benzoyl chloride is synthesized through chlorination, fluorination, hydrolysis, acylating chlorination and rectification reaction in sequence, and the invention further provides ceramic balls, a modified TPU material and a fluorination auxiliary agent used in the synthesis method of the o-trifluoromethyl benzoyl chloride. According to the method, the low-toxicity color liquid o-xylene is adopted as the initial raw material, the reaction safety is high, and the yield of the target product o-trifluoromethyl benzoyl chloride is comprehensively improved by improving the utilization rate of chlorine and hydrogen fluoride and reducing by-products.
本发明公开了一种邻三氟甲基苯甲酰氯的合成方法，以邻二甲苯为起始原料，依次通过氯化、氟化、水解、酰氯化和精馏反应合成邻三氟甲基甲酰氯，本发明还提供了用于邻三氟甲基苯甲酰氯的合成方法中的陶瓷球、改性TPU材料以及氟化助剂。本发明采用低毒的物色液体邻二甲苯为起始原料，反应安全性高，且通过提高氯气和氟化氢的利用率，减少了副产物，综合提高了目标产物邻三氟甲基苯甲酰氯的收率。
Synthetic method of o-trifluoromethyl benzoyl chloride
The invention discloses a synthesis method of o-trifluoromethyl benzoyl chloride, o-xylene is used as a starting raw material, the o-trifluoromethyl benzoyl chloride is synthesized through chlorination, fluorination, hydrolysis, acylating chlorination and rectification reaction in sequence, and the invention further provides ceramic balls, a modified TPU material and a fluorination auxiliary agent used in the synthesis method of the o-trifluoromethyl benzoyl chloride. According to the method, the low-toxicity color liquid o-xylene is adopted as the initial raw material, the reaction safety is high, and the yield of the target product o-trifluoromethyl benzoyl chloride is comprehensively improved by improving the utilization rate of chlorine and hydrogen fluoride and reducing by-products.
本发明公开了一种邻三氟甲基苯甲酰氯的合成方法，以邻二甲苯为起始原料，依次通过氯化、氟化、水解、酰氯化和精馏反应合成邻三氟甲基甲酰氯，本发明还提供了用于邻三氟甲基苯甲酰氯的合成方法中的陶瓷球、改性TPU材料以及氟化助剂。本发明采用低毒的物色液体邻二甲苯为起始原料，反应安全性高，且通过提高氯气和氟化氢的利用率，减少了副产物，综合提高了目标产物邻三氟甲基苯甲酰氯的收率。
Synthetic method of o-trifluoromethyl benzoyl chloride
一种邻三氟甲基苯甲酰氯的合成方法
LI QUAN (author) / LI XING (author) / YANG ZHAOFENG (author) / WU CHANGFU (author)
2022-03-18
Patent
Electronic Resource
Chinese
IPC:
C07C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
,
Acyclische oder carbocyclische Verbindungen
/
C04B
Kalk
,
LIME
/
C08K
Verwendung von anorganischen oder nichtmakromolekularen organischen Stoffen als Zusatzstoffe
,
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES AS COMPOUNDING INGREDIENTS
/
C08L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
,
Massen auf Basis makromolekularer Verbindungen
CANCER AMONG BENZOYL CHLORIDE MANUFACTURING WORKERS
| Wiley | 1976
Reactivity of Carboxamides toward Benzoyl Chloride in Acetonitrile
| British Library Online Contents | 2001
Reactivity of Pyridines and Pyridine N-Oxides toward Benzoyl Chloride in Acetonitrile
| British Library Online Contents | 2000
| British Library Online Contents | 2002