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Modified hydroxyapatite, composite bone cement as well as preparation method and application of modified hydroxyapatite and composite bone cement
The invention discloses modified hydroxyapatite, composite bone cement as well as a preparation method and application of the modified hydroxyapatite and the composite bone cement. The preparation method of the modified hydroxyapatite comprises the following steps: sintering hydroxyapatite and graphite to obtain the modified hydroxyapatite, the particle size D50 of the graphite is 10 nm to 48 [mu] m; the sintering temperature is 900 to 1700 DEG C; the sintering environment is vacuum or inert atmosphere. The prepared modified hydroxyapatite is compounded with magnesium phosphate bone cement, and the prepared composite bone cement has better photo-thermal conversion capability, photo-thermal anti-tumor performance and photo-thermal antibacterial performance, and is higher in cell adhesion rate, OD value and ALP activity.
本发明公开了一种改性羟基磷灰石、复合骨水泥及其制备方法和应用。该改性羟基磷灰石的制备方法包括以下步骤:羟基磷灰石与石墨进行烧结,得改性羟基磷灰石;所述石墨的粒径D50为10nm~48μm;所述烧结的温度为900~1700℃;所述烧结的环境为真空或惰性气氛。本发明制得的改性羟基磷灰石与磷酸镁骨水泥复配,制得的复合骨水泥具有较佳地光热转换能力、光热抗肿瘤和光热抗菌,且细胞粘附率、OD值和ALP活性均较高。
Modified hydroxyapatite, composite bone cement as well as preparation method and application of modified hydroxyapatite and composite bone cement
The invention discloses modified hydroxyapatite, composite bone cement as well as a preparation method and application of the modified hydroxyapatite and the composite bone cement. The preparation method of the modified hydroxyapatite comprises the following steps: sintering hydroxyapatite and graphite to obtain the modified hydroxyapatite, the particle size D50 of the graphite is 10 nm to 48 [mu] m; the sintering temperature is 900 to 1700 DEG C; the sintering environment is vacuum or inert atmosphere. The prepared modified hydroxyapatite is compounded with magnesium phosphate bone cement, and the prepared composite bone cement has better photo-thermal conversion capability, photo-thermal anti-tumor performance and photo-thermal antibacterial performance, and is higher in cell adhesion rate, OD value and ALP activity.
本发明公开了一种改性羟基磷灰石、复合骨水泥及其制备方法和应用。该改性羟基磷灰石的制备方法包括以下步骤:羟基磷灰石与石墨进行烧结,得改性羟基磷灰石;所述石墨的粒径D50为10nm~48μm;所述烧结的温度为900~1700℃;所述烧结的环境为真空或惰性气氛。本发明制得的改性羟基磷灰石与磷酸镁骨水泥复配,制得的复合骨水泥具有较佳地光热转换能力、光热抗肿瘤和光热抗菌,且细胞粘附率、OD值和ALP活性均较高。
Modified hydroxyapatite, composite bone cement as well as preparation method and application of modified hydroxyapatite and composite bone cement
一种改性羟基磷灰石、复合骨水泥及其制备方法和应用
SUN PING (author) / LI FENGQIAN (author) / ZHAN YANLEI (author) / HU HAI (author) / LAN SHENGHUI (author) / WEI JIE (author)
2022-06-14
Patent
Electronic Resource
Chinese
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