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Cancellous bone defect filler and preparation method thereof
The invention discloses a cancellous bone defect-like filler and a preparation method thereof, and belongs to the technical field of medical treatment. The method comprises the following steps: fully dissolving 2-6wt% of a degradable polymer freeze-drying medium and 30-40wt% of sterilized water for injection, and then uniformly stirring with 50-60wt% of inorganic powder (one or more of hydroxyapatite, beta-tricalcium phosphate, calcium silicate, bioactive glass, calcium carbonate or calcined bone meal) with biological activity to obtain paste with certain viscosity. The paste is loaded into a charging barrel, bubbles in the paste are removed through high-speed centrifugation, a porous bone scaffold is subjected to non-wire extrusion type 3D printing, then freeze-thaw circulation and freeze-drying are conducted, and the cancellous bone-like filler with the high micropore and macropore communication rate is prepared. After the cancellous bone defect filler is freeze-dried, the micropore water absorption rate is 65.2%-74.6%, no inorganic powder is separated out after the filler is soaked in simulated body fluid for 2 weeks, the risk of granulation swelling in the early stage of implantation can be effectively reduced, and the filler is also beneficial to inducing regular growth of new bones.
本发明公开了一种类松质骨骨缺损填充物及其制备方法，属于医疗技术领域。该方法通过将2～6wt.％的可降解高分子冻干介质和30～40wt.％灭菌注射用水充分溶解，然后与50～60wt.％具有生物活性的无机粉料(羟基磷灰石、β‑磷酸三钙、硅酸钙、生物活性玻璃、碳酸钙或煅烧骨粉中的一种或多种)搅拌均匀，得到具有一定粘性的膏体。接着将该膏体装入料筒经高速离心去除其中的气泡，经无丝挤出式3D打印多孔骨支架，再经冻融循环、冻干，制得微孔和宏孔连通率均较高的类松质骨填充物。该类松质骨骨缺损填充物冻干后的微孔吸水率为65.2％～74.6％，且在模拟体液中浸泡2周均无无机粉料析出，可有效降低植入前期肉芽包肿的风险，还有利于诱导新骨规则生长。
Cancellous bone defect filler and preparation method thereof
The invention discloses a cancellous bone defect-like filler and a preparation method thereof, and belongs to the technical field of medical treatment. The method comprises the following steps: fully dissolving 2-6wt% of a degradable polymer freeze-drying medium and 30-40wt% of sterilized water for injection, and then uniformly stirring with 50-60wt% of inorganic powder (one or more of hydroxyapatite, beta-tricalcium phosphate, calcium silicate, bioactive glass, calcium carbonate or calcined bone meal) with biological activity to obtain paste with certain viscosity. The paste is loaded into a charging barrel, bubbles in the paste are removed through high-speed centrifugation, a porous bone scaffold is subjected to non-wire extrusion type 3D printing, then freeze-thaw circulation and freeze-drying are conducted, and the cancellous bone-like filler with the high micropore and macropore communication rate is prepared. After the cancellous bone defect filler is freeze-dried, the micropore water absorption rate is 65.2%-74.6%, no inorganic powder is separated out after the filler is soaked in simulated body fluid for 2 weeks, the risk of granulation swelling in the early stage of implantation can be effectively reduced, and the filler is also beneficial to inducing regular growth of new bones.
本发明公开了一种类松质骨骨缺损填充物及其制备方法，属于医疗技术领域。该方法通过将2～6wt.％的可降解高分子冻干介质和30～40wt.％灭菌注射用水充分溶解，然后与50～60wt.％具有生物活性的无机粉料(羟基磷灰石、β‑磷酸三钙、硅酸钙、生物活性玻璃、碳酸钙或煅烧骨粉中的一种或多种)搅拌均匀，得到具有一定粘性的膏体。接着将该膏体装入料筒经高速离心去除其中的气泡，经无丝挤出式3D打印多孔骨支架，再经冻融循环、冻干，制得微孔和宏孔连通率均较高的类松质骨填充物。该类松质骨骨缺损填充物冻干后的微孔吸水率为65.2％～74.6％，且在模拟体液中浸泡2周均无无机粉料析出，可有效降低植入前期肉芽包肿的风险，还有利于诱导新骨规则生长。
Cancellous bone defect filler and preparation method thereof
一种类松质骨骨缺损填充物及其制备方法
ZENG QINGFENG (author) / HE RUI (author) / WEI JING (author) / SONG JIAYIN (author) / YI MINGXING (author) / FANG LIANG (author) / ZHANG XINPING (author)
2022-12-13
Patent
Electronic Resource
Chinese
IPC:
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
/
C04B
Kalk
,
LIME
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