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Photocuring 3D printing minimum curved surface artificial bone scaffold and preparation method thereof
The invention discloses a photocuring 3D printing minimum curved surface artificial bone scaffold and a preparation method thereof. A calcium phosphate ceramic/bioglass composite ceramic scaffold is prepared by using a photocuring 3D printing technology. According to the photocuring 3D printing minimum curved surface artificial bone scaffold and the preparation method thereof, the structural gradient bionic scaffold is constructed through structural hybridization design, and the internal high permeability and the external high-strength pore structure of the structural gradient bionic scaffold provide an efficient material transport channel and strong mechanical support for large-segment bone defects; by combining the introduction of magnesium ions and molybdenum ions in the bioglass, active ions can be continuously released in the implantation process, the osteoclast activity is inhibited, the osteogenic differentiation is promoted, the problem of adaptability between the mechanical property of the scaffold and the osteogenic activity in bone defect repair is effectively improved, and the osteogenic ability of the ceramic scaffold is improved.
本发明公开了一种光固化3D打印最小曲面人工骨支架及其制备方法，利用光固化3D打印技术制备了磷酸钙类陶瓷/生物玻璃复合陶瓷支架。本发明的一种光固化3D打印最小曲面人工骨支架及其制备方法通过结构杂交设计构建结构梯度仿生支架，其内部高渗透性和外部高强度小孔结构为大段骨缺损提供高效物质运输通道和强力学支撑，并结合生物玻璃中镁离子和钼离子的引入，在植入过程中的可持续释放活性离子，抑制破骨细胞活性、促进成骨分化，有效改善了骨缺损修复中支架力学性能与成骨活性的适配性问题，提高了陶瓷支架的成骨能力。
Photocuring 3D printing minimum curved surface artificial bone scaffold and preparation method thereof
The invention discloses a photocuring 3D printing minimum curved surface artificial bone scaffold and a preparation method thereof. A calcium phosphate ceramic/bioglass composite ceramic scaffold is prepared by using a photocuring 3D printing technology. According to the photocuring 3D printing minimum curved surface artificial bone scaffold and the preparation method thereof, the structural gradient bionic scaffold is constructed through structural hybridization design, and the internal high permeability and the external high-strength pore structure of the structural gradient bionic scaffold provide an efficient material transport channel and strong mechanical support for large-segment bone defects; by combining the introduction of magnesium ions and molybdenum ions in the bioglass, active ions can be continuously released in the implantation process, the osteoclast activity is inhibited, the osteogenic differentiation is promoted, the problem of adaptability between the mechanical property of the scaffold and the osteogenic activity in bone defect repair is effectively improved, and the osteogenic ability of the ceramic scaffold is improved.
本发明公开了一种光固化3D打印最小曲面人工骨支架及其制备方法，利用光固化3D打印技术制备了磷酸钙类陶瓷/生物玻璃复合陶瓷支架。本发明的一种光固化3D打印最小曲面人工骨支架及其制备方法通过结构杂交设计构建结构梯度仿生支架，其内部高渗透性和外部高强度小孔结构为大段骨缺损提供高效物质运输通道和强力学支撑，并结合生物玻璃中镁离子和钼离子的引入，在植入过程中的可持续释放活性离子，抑制破骨细胞活性、促进成骨分化，有效改善了骨缺损修复中支架力学性能与成骨活性的适配性问题，提高了陶瓷支架的成骨能力。
Photocuring 3D printing minimum curved surface artificial bone scaffold and preparation method thereof
一种光固化3D打印最小曲面人工骨支架及其制备方法
DAI HONGLIAN (author) / YE FAN (author) / YANG HE (author) / HONG CHUHANG (author) / TU RONG (author)
2023-11-28
Patent
Electronic Resource
Chinese
IPC:
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
/
C03C
Chemische Zusammensetzungen für Gläser, Glasuren oder Emails
,
CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUS ENAMELS
/
C04B
Kalk
,
LIME
/
G06F
ELECTRIC DIGITAL DATA PROCESSING
,
Elektrische digitale Datenverarbeitung
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