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The present invention provides a cost-efficient method for producing particles having a SiO2 containing surface wherein said method comprises a) providing an aqueous reaction composition comprising i) core particles, ii) an added base, iii) a silicate salt, and iv) a pH modulator wherein the pH value of the reaction composition is above the gelation pH value; b) agitating said reaction composition, wherein the pH modulator decreases the pH value of the reaction composition over time and wherein due to said decrease of the pH value of the reaction composition SiO2 is deposited onto the core particles, whereby particles are formed which have a diameter of 30 μm or less; and c) obtaining the particles. Furthermore, silica particles having high nucleic acid binding properties are provided.
The present invention provides a cost-efficient method for producing particles having a SiO2 containing surface wherein said method comprises a) providing an aqueous reaction composition comprising i) core particles, ii) an added base, iii) a silicate salt, and iv) a pH modulator wherein the pH value of the reaction composition is above the gelation pH value; b) agitating said reaction composition, wherein the pH modulator decreases the pH value of the reaction composition over time and wherein due to said decrease of the pH value of the reaction composition SiO2 is deposited onto the core particles, whereby particles are formed which have a diameter of 30 μm or less; and c) obtaining the particles. Furthermore, silica particles having high nucleic acid binding properties are provided.
Preparation of silica particles
FABIS ROLAND (author)
2018-04-10
Patent
Electronic Resource
English
IPC:
B32B
LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
,
Schichtkörper, d.h. aus Ebenen oder gewölbten Schichten, z.B. mit zell- oder wabenförmiger Form, aufgebaute Erzeugnisse
/
C01B
NON-METALLIC ELEMENTS
,
Nichtmetallische Elemente
/
C01G
Verbindungen der von den Unterklassen C01D oder C01F nicht umfassten Metalle
,
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
/
C04B
Kalk
,
LIME
/
C09C
TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES
,
Behandlung von anorganischen Stoffen, außer von faserigen Füllstoffen, zum Erhöhen ihrer pigmentierenden oder füllenden Eigenschaften
/
C12N
Mikroorganismen oder Enzyme
,
MICROORGANISMS OR ENZYMES
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