A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Inhibitory effect of trihydroxyisoflavone family for a candidate target MECOM for glioblastoma multiforme
Glioblastoma multiforme, a type of brain cancer, emerged from glia or precursors in the central nervous system. MDS1 and EVI1 complex locus protein (MECOM), a nuclear oncogenic zinc finger transcription factor, reported to be overexpressed in disease and lead to pathogenesis. In this study, we assessed physiochemical properties and drug-likeness properties of five ligands from Glycine max L. (Soybean) and their interaction with MECOM protein. The chemical properties were assessed using the SWISS-ADME web tool and Autodock Vina was used for molecular interactions. The results showed that the ligand 6, 7, 4′-Trihydroxyisoflavone potentially binds (ΔG = 7.2 kcal/mol) to the target MECOM protein with lower ADMET properties violations. Hence, the ligand 6, 7, 4′-Trihydroxyisoflavone is used as a potential inhibitor for MECOM protein. Conversely, this study can be used as a preliminary fact intended for validation.
Inhibitory effect of trihydroxyisoflavone family for a candidate target MECOM for glioblastoma multiforme
Glioblastoma multiforme, a type of brain cancer, emerged from glia or precursors in the central nervous system. MDS1 and EVI1 complex locus protein (MECOM), a nuclear oncogenic zinc finger transcription factor, reported to be overexpressed in disease and lead to pathogenesis. In this study, we assessed physiochemical properties and drug-likeness properties of five ligands from Glycine max L. (Soybean) and their interaction with MECOM protein. The chemical properties were assessed using the SWISS-ADME web tool and Autodock Vina was used for molecular interactions. The results showed that the ligand 6, 7, 4′-Trihydroxyisoflavone potentially binds (ΔG = 7.2 kcal/mol) to the target MECOM protein with lower ADMET properties violations. Hence, the ligand 6, 7, 4′-Trihydroxyisoflavone is used as a potential inhibitor for MECOM protein. Conversely, this study can be used as a preliminary fact intended for validation.
Inhibitory effect of trihydroxyisoflavone family for a candidate target MECOM for glioblastoma multiforme
Vidhya, D. (author) / Vanathi, P. (author) / Mansoor, Wathiq (author) / Singh, Balbir (author)
2022-02-21
1291919 byte
Conference paper
Electronic Resource
English
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