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Enantioselective disruption of the endocrine system by Cis‐Bifenthrin in the male mice
Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF is a mixed compound containing cis isomers (cis‐BF) including two enantiomers of 1R‐cis‐BF and 1S‐cis‐BF. In the present study, the two individual cis‐BF enantiomers were separated by a preparative supercritical fluid chromatography. Then, four week‐old adolescent male ICR mice were orally administered 1R‐cis‐BF and 1S‐cis‐BF separately daily for 3 weeks at doses of 0, 7.5 and 15 mg/kg/day, respectively. Results showed that the transcription status of some genes involved in cholesterol synthesis and transport as well as testosterone (T) synthesis in the testes were influenced by cis‐BF enantiomers. Especially, we observed that the transcription status of key genes on the pathway of T synthesis including cytochrome P450 cholesterol side‐chain cleavage enzyme (P450scc) and cytochrome P450 17α‐hydroxysteroid dehydrogenase (P45017α)) were selectively altered in the testis of mice when treated with 1S‐cis‐BF, suggesting that it is the possible reason to explain why the lower serum T concentration in 1S‐cis‐BF treated group. Taken together, it concluded that both of the cis‐BF enantiomers have the endocrine disruption activities, while 1S‐cis‐BF was higher than 1R‐cis‐BF in mice when exposed during the puberty. The data was helpful to understand the toxicity of cis‐BF in mammals under enantiomeric level. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 746–754, 2015.
Enantioselective disruption of the endocrine system by Cis‐Bifenthrin in the male mice
Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF is a mixed compound containing cis isomers (cis‐BF) including two enantiomers of 1R‐cis‐BF and 1S‐cis‐BF. In the present study, the two individual cis‐BF enantiomers were separated by a preparative supercritical fluid chromatography. Then, four week‐old adolescent male ICR mice were orally administered 1R‐cis‐BF and 1S‐cis‐BF separately daily for 3 weeks at doses of 0, 7.5 and 15 mg/kg/day, respectively. Results showed that the transcription status of some genes involved in cholesterol synthesis and transport as well as testosterone (T) synthesis in the testes were influenced by cis‐BF enantiomers. Especially, we observed that the transcription status of key genes on the pathway of T synthesis including cytochrome P450 cholesterol side‐chain cleavage enzyme (P450scc) and cytochrome P450 17α‐hydroxysteroid dehydrogenase (P45017α)) were selectively altered in the testis of mice when treated with 1S‐cis‐BF, suggesting that it is the possible reason to explain why the lower serum T concentration in 1S‐cis‐BF treated group. Taken together, it concluded that both of the cis‐BF enantiomers have the endocrine disruption activities, while 1S‐cis‐BF was higher than 1R‐cis‐BF in mice when exposed during the puberty. The data was helpful to understand the toxicity of cis‐BF in mammals under enantiomeric level. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 746–754, 2015.
Enantioselective disruption of the endocrine system by Cis‐Bifenthrin in the male mice
Jin, Yuanxiang (author) / Wang, Jiangcong / Pan, Xiuhong / Miao, Wenyu / Lin, Xiaojian / Wang, Linggang / Fu, Zhengwei
2015
Article (Journal)
English
Cis‐bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice
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