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Protective effect of taurine against potassium bromate‐induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood
Potassium bromate (KBrO 3 ) is widely used as a food‐additive and is a major water disinfection by‐product. KBrO 3 causes severe toxicity in humans and experimental animals. Bromate is considered a probable human carcinogen and a complete carcinogen in animals. We have investigated the potential role of taurine in protecting against KBrO 3 ‐induced oxidative stress in rat blood. Animals were given taurine for 5 days prior to KBrO 3 and then sacrificed. Blood was collected and used to prepare hemolysates and plasma, which were then used for the analysis of several biochemical parameters. Administration of single oral dose of KBrO 3 alone induced hepato‐ and nephro‐toxicity as evident by elevated marker levels in plasma. Lipid peroxidation and protein oxidation were increased both in plasma and erythrocytes, suggesting the induction of oxidative stress. KBrO 3 increased methemoglobin, nitric oxide, and hydrogen peroxide levels. It also altered the activities of the major antioxidant enzymes and lowered the antioxidant power of blood. Administration of taurine, prior to treatment with KBrO 3 , resulted in significant attenuation in all these parameters but the administration of taurine alone had no effect. These results show that taurine is effective in mitigating the oxidative insult induced in rat blood by KBrO 3 . © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 304–313, 2016.
Protective effect of taurine against potassium bromate‐induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood
Potassium bromate (KBrO 3 ) is widely used as a food‐additive and is a major water disinfection by‐product. KBrO 3 causes severe toxicity in humans and experimental animals. Bromate is considered a probable human carcinogen and a complete carcinogen in animals. We have investigated the potential role of taurine in protecting against KBrO 3 ‐induced oxidative stress in rat blood. Animals were given taurine for 5 days prior to KBrO 3 and then sacrificed. Blood was collected and used to prepare hemolysates and plasma, which were then used for the analysis of several biochemical parameters. Administration of single oral dose of KBrO 3 alone induced hepato‐ and nephro‐toxicity as evident by elevated marker levels in plasma. Lipid peroxidation and protein oxidation were increased both in plasma and erythrocytes, suggesting the induction of oxidative stress. KBrO 3 increased methemoglobin, nitric oxide, and hydrogen peroxide levels. It also altered the activities of the major antioxidant enzymes and lowered the antioxidant power of blood. Administration of taurine, prior to treatment with KBrO 3 , resulted in significant attenuation in all these parameters but the administration of taurine alone had no effect. These results show that taurine is effective in mitigating the oxidative insult induced in rat blood by KBrO 3 . © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 304–313, 2016.
Protective effect of taurine against potassium bromate‐induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood
Ahmad, Mir Kaisar (author) / Mahmood, Riaz
2016
Article (Journal)
English
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