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A simple in-host model for Mycobacterium tuberculosis that captures all infection outcomes
Tuberculosis infection can result in clearance, latent infection, or active disease, with slow or fast progression. A four-dimensional model of in-host tuberculosis infection includes macrophages, T lymphocytes, tuberculosis bacteria, and their interactions. Changes in the infection rate, cell-mediated immunity rate, macrophage loss rate, and bacteria killing rate most affect disease outcomes. Simulations show that a periodic solution can occur. When the infected macrophage killing rate is constant, a backward bifurcation exists and the system is globally stable.
A simple in-host model for Mycobacterium tuberculosis that captures all infection outcomes
Tuberculosis infection can result in clearance, latent infection, or active disease, with slow or fast progression. A four-dimensional model of in-host tuberculosis infection includes macrophages, T lymphocytes, tuberculosis bacteria, and their interactions. Changes in the infection rate, cell-mediated immunity rate, macrophage loss rate, and bacteria killing rate most affect disease outcomes. Simulations show that a periodic solution can occur. When the infected macrophage killing rate is constant, a backward bifurcation exists and the system is globally stable.
A simple in-host model for Mycobacterium tuberculosis that captures all infection outcomes
Yimin Du (author) / Jianhong Wu / Jane M Heffernan
2017
Article (Journal)
English
Local classification TIB:
770/1905/3175
BKL:
42.11
Biomathematik, Biokybernetik
/
74.80
Demographie
/
31.73
Mathematische Statistik
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