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Nanosilver particles increase follicular atresia: Correlation with oxidative stress and aromatization
Present study was performed in order to update the possible mechanism(s), involving in nanosilver particles (NSPs)‐induced detrimental impacts in ovarian tissue. For this purpose, 24 mature female rats were divided into control and 0.5, 1, 5 mg/kg NSPs‐received groups (intraperitoneally, for 35 days). Follicular growth and atresia, ovarian total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) contents, serum estrogen (E 2 ) level and macrophages infiltration were investigated. Moreover, ovarian angiogenesis, cellular mRNA damage and cytochrome aromatase CYP19 expression were analyzed. The NSPs enhanced follicular atresia diminished E 2, reduced TAC and SOD level, elevated MDA content and up‐regulated macrophages infiltration. Cellular mRNA damage, impaired angiogenesis and diminished CYP19 expression were revealed in NSPs‐received groups. Therefore NSPs by down‐regulating aromatization, reduce E 2 synthesis which then it leads to impaired angiogenesis. The impaired angiogenesis in turn down‐regulates ovarian antioxidant status, which partially enhances follicular atresia by triggering lipid peroxidation and mRNA damage.
Nanosilver particles increase follicular atresia: Correlation with oxidative stress and aromatization
Present study was performed in order to update the possible mechanism(s), involving in nanosilver particles (NSPs)‐induced detrimental impacts in ovarian tissue. For this purpose, 24 mature female rats were divided into control and 0.5, 1, 5 mg/kg NSPs‐received groups (intraperitoneally, for 35 days). Follicular growth and atresia, ovarian total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) contents, serum estrogen (E 2 ) level and macrophages infiltration were investigated. Moreover, ovarian angiogenesis, cellular mRNA damage and cytochrome aromatase CYP19 expression were analyzed. The NSPs enhanced follicular atresia diminished E 2, reduced TAC and SOD level, elevated MDA content and up‐regulated macrophages infiltration. Cellular mRNA damage, impaired angiogenesis and diminished CYP19 expression were revealed in NSPs‐received groups. Therefore NSPs by down‐regulating aromatization, reduce E 2 synthesis which then it leads to impaired angiogenesis. The impaired angiogenesis in turn down‐regulates ovarian antioxidant status, which partially enhances follicular atresia by triggering lipid peroxidation and mRNA damage.
Nanosilver particles increase follicular atresia: Correlation with oxidative stress and aromatization
Mirzaei, Masumeh (author) / Razi, Mazdak / Sadrkhanlou, Rajabali
2017
Article (Journal)
English
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