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Mechanical and In Vitro Analysis of 3D Printed Silk Fibroin/Bone/Polycaprolactone/Chitosan Composite Scaffolds
https://orcid.org/http://orcid.org/0000-0002-9646-9692
Bone grafting remains the primary treatment for orthopedic injuries, diseases, and fractures; however, when impractical, bone tissue engineering offers scaffolding as an alternative. This study aims to develop composite biomaterial inks for 3D bioprinting of scaffolds using silk fibroin (SF), bone particles (B), synthetic biopolymer poly (ε-caprolactone) (PCL), and chitosan (C). The biomechanical, structural, and biological properties of the composite scaffolds were examined to assess their suitability for bone tissue formation. In vitro bioactivity in simulated body fluids, swelling, and degradation properties were also assessed. Results indicate that bovine bone particles enhance the mechanical endurance of silk fibroin-based composite scaffolds and increase their ability to produce hydroxyapatite in vitro. Overall, these findings suggest that 3D printed bio-composite scaffolds mimic real bone features and can be utilized for bone tissue regeneration and restoration.
Mechanical and In Vitro Analysis of 3D Printed Silk Fibroin/Bone/Polycaprolactone/Chitosan Composite Scaffolds
https://orcid.org/http://orcid.org/0000-0002-9646-9692
Bone grafting remains the primary treatment for orthopedic injuries, diseases, and fractures; however, when impractical, bone tissue engineering offers scaffolding as an alternative. This study aims to develop composite biomaterial inks for 3D bioprinting of scaffolds using silk fibroin (SF), bone particles (B), synthetic biopolymer poly (ε-caprolactone) (PCL), and chitosan (C). The biomechanical, structural, and biological properties of the composite scaffolds were examined to assess their suitability for bone tissue formation. In vitro bioactivity in simulated body fluids, swelling, and degradation properties were also assessed. Results indicate that bovine bone particles enhance the mechanical endurance of silk fibroin-based composite scaffolds and increase their ability to produce hydroxyapatite in vitro. Overall, these findings suggest that 3D printed bio-composite scaffolds mimic real bone features and can be utilized for bone tissue regeneration and restoration.
Mechanical and In Vitro Analysis of 3D Printed Silk Fibroin/Bone/Polycaprolactone/Chitosan Composite Scaffolds
https://orcid.org/http://orcid.org/0000-0002-9646-9692
Bone grafting remains the primary treatment for orthopedic injuries, diseases, and fractures; however, when impractical, bone tissue engineering offers scaffolding as an alternative. This study aims to develop composite biomaterial inks for 3D bioprinting of scaffolds using silk fibroin (SF), bone particles (B), synthetic biopolymer poly (ε-caprolactone) (PCL), and chitosan (C). The biomechanical, structural, and biological properties of the composite scaffolds were examined to assess their suitability for bone tissue formation. In vitro bioactivity in simulated body fluids, swelling, and degradation properties were also assessed. Results indicate that bovine bone particles enhance the mechanical endurance of silk fibroin-based composite scaffolds and increase their ability to produce hydroxyapatite in vitro. Overall, these findings suggest that 3D printed bio-composite scaffolds mimic real bone features and can be utilized for bone tissue regeneration and restoration.
Mechanical and In Vitro Analysis of 3D Printed Silk Fibroin/Bone/Polycaprolactone/Chitosan Composite Scaffolds
J. Inst. Eng. India Ser. C
Ansari, Ali Imran (author) / Sheikh, Nazir Ahmad (author)
Journal of The Institution of Engineers (India): Series C ; 105 ; 1413-1428
2024-12-01
16 pages
Article (Journal)
Electronic Resource
English
Silk fibroin/Chitosan based composites ink , Chitosan/Bovine bone particles based composites ink , Bone 3D bioprinting , 3D printed composites scaffolds Engineering , Biomedical Engineering , Medical and Health Sciences , Clinical Sciences , Aerospace Technology and Astronautics , Mechanical Engineering , Industrial and Production Engineering
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Study on Tissue Engineering Scaffolds of Silk Fibroin-Chitosan/ Nano-Hydroxyapatite Composite
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| British Library Online Contents | 2017
| British Library Online Contents | 2017