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SARS-CoV-2 Infection Dynamics Integrated with Mucociliary Transport in Human Upper Airway
The purpose of this study was to accurately predict the dynamics of SARS-CoV-2 infection–based on a 3D shell model and combining computational fluid and particle dynamics (CFPD) and host-cell dynamics–along the mucus layer of the upper airway. Assuming that a healthy person inhaled droplets coughed up by an infected individual via nasal inhalation, we focused on the infection dynamics of the virus deposited in the nasal cavity and nasopharynx. The distribution of the cough droplets deposited was preliminarily analyzed using CFPD. Using this distribution as an initial condition, we predicted the time series distribution for SARS-CoV-2 concentration in the mucus milieu depending on diffusion, mucociliary motion, and virus production. These results form an initial elucidation of an aspect of the virus’ transmission mechanism in the upper airway.
SARS-CoV-2 Infection Dynamics Integrated with Mucociliary Transport in Human Upper Airway
The purpose of this study was to accurately predict the dynamics of SARS-CoV-2 infection–based on a 3D shell model and combining computational fluid and particle dynamics (CFPD) and host-cell dynamics–along the mucus layer of the upper airway. Assuming that a healthy person inhaled droplets coughed up by an infected individual via nasal inhalation, we focused on the infection dynamics of the virus deposited in the nasal cavity and nasopharynx. The distribution of the cough droplets deposited was preliminarily analyzed using CFPD. Using this distribution as an initial condition, we predicted the time series distribution for SARS-CoV-2 concentration in the mucus milieu depending on diffusion, mucociliary motion, and virus production. These results form an initial elucidation of an aspect of the virus’ transmission mechanism in the upper airway.
SARS-CoV-2 Infection Dynamics Integrated with Mucociliary Transport in Human Upper Airway
Environ Sci Eng
Wang, Liangzhu Leon (editor) / Ge, Hua (editor) / Zhai, Zhiqiang John (editor) / Qi, Dahai (editor) / Ouf, Mohamed (editor) / Sun, Chanjuan (editor) / Wang, Dengjia (editor) / Li, Hanyu (author) / Kuga, Kazuki (author) / Ito, Kazuhide (author)
International Conference on Building Energy and Environment ; 2022
Proceedings of the 5th International Conference on Building Energy and Environment ; Chapter: 170 ; 1649-1652
2023-09-05
4 pages
Article/Chapter (Book)
Electronic Resource
English
SARS-CoV-2 , Upper respiratory tract , Mucociliary transport , Mucus layer , Computational fluid and particle dynamics , Host-cell dynamics Engineering , Building Physics, HVAC , Fire Science, Hazard Control, Building Safety , Sustainable Architecture/Green Buildings , Renewable and Green Energy , Environment, general
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