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Toxicity Reference Values for Polybrominated Diphenyl Ethers: Risk Assessment for Predatory Birds and Mammals from Two Chinese Lakes
Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants (BFRs), that are widely used in products such as polymer resins, furniture and plastics (Environment Canada 2006). However, PBDEs have been recognized as persistent and bioaccumulative pollutants that can undergo long-range atmospheric transport (De Wit et al. 2006). Based on thresholds for effects of PBDEs on animals under laboratory conditions, PBDEs could accumulate to sufficient concentrations so as to pose a dietary risk to wildlife (Environment Canada 2006; Bureau 2001). Some PBDE congeners can bind to the arylhydrocarbon receptor (AhR), but the binding affinities are very weak or negligible (ATSDR 2004). PBDEs can affect neurobehavioral development, thyroid hormone concentrations in blood plasma, fetal development, reproductive performance, intracellular signaling processes, and also have estrogenic potency (Fernie et al. 2009; Darnerud 2003; ATSDR 2004). Therefore, production and use of some PBDEs technical mixtures have been banned or phased out in most countries (Gao et al. 2009a).
Toxicity Reference Values for Polybrominated Diphenyl Ethers: Risk Assessment for Predatory Birds and Mammals from Two Chinese Lakes
Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants (BFRs), that are widely used in products such as polymer resins, furniture and plastics (Environment Canada 2006). However, PBDEs have been recognized as persistent and bioaccumulative pollutants that can undergo long-range atmospheric transport (De Wit et al. 2006). Based on thresholds for effects of PBDEs on animals under laboratory conditions, PBDEs could accumulate to sufficient concentrations so as to pose a dietary risk to wildlife (Environment Canada 2006; Bureau 2001). Some PBDE congeners can bind to the arylhydrocarbon receptor (AhR), but the binding affinities are very weak or negligible (ATSDR 2004). PBDEs can affect neurobehavioral development, thyroid hormone concentrations in blood plasma, fetal development, reproductive performance, intracellular signaling processes, and also have estrogenic potency (Fernie et al. 2009; Darnerud 2003; ATSDR 2004). Therefore, production and use of some PBDEs technical mixtures have been banned or phased out in most countries (Gao et al. 2009a).
Toxicity Reference Values for Polybrominated Diphenyl Ethers: Risk Assessment for Predatory Birds and Mammals from Two Chinese Lakes
Reviews Env.Contamination(formerly:Residue Reviews)
Whitacre, David M. (editor) / Zhang, Ruiqing (author) / Guo, Jianyang (author) / Wu, Fengchang (author) / Mu, Yunsong (author) / Giesy, John P. (author) / Chang, Hong (author) / Zhao, Xiaoli (author) / Feng, Chenglian (author)
Reviews of Environmental Contamination and Toxicology ; Chapter: 6 ; 229 ; 111-137
2013-12-31
27 pages
Article/Chapter (Book)
Electronic Resource
English
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