A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Macromolecular Design of New Synthetic Biodegradable Medical Polymers
Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences
Abstract The use of polymeric biomaterials in health care, medicine and pharmaceutics presently comprises variety of applications, ranging from contact lenses, prosthetic devices, and wound healing materials, to drugs delivery systems and, increasingly also, materials for cell therapies and tissue repair and engineering.[l, 2] Though, the use of polymers as an artificial extracellular matrix and a support for tissue regeneration promises exciting perspectives for medicine, at the same time, it also poses a major challenge to the fundamental science interfacing the polymer chemistry and cell biology. The materials sought as templates for implanted cells, or as a support for tissue regeneration, must fulfill rather complex requirements, among which two issues become increasingly important: (a) a controlled biodegradability of the polymer matrix, and (b) polymer-cell and/or polymer -tissue interactions.[l, 3] In the past decade, significant advances have been made in understanding the ways in which cells interact with their natural environment of extracellular-matrix proteins.[4] This knowledge has laid the foundation for the rational design of polymers that could play an active role in tissue regeneration and repair. New polymers and their supramolecular constructs, tailored to provoke a physiological response such as growth and differentiation of cells in a controlled way, are being sought. [5, 6]
Macromolecular Design of New Synthetic Biodegradable Medical Polymers
Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences
Abstract The use of polymeric biomaterials in health care, medicine and pharmaceutics presently comprises variety of applications, ranging from contact lenses, prosthetic devices, and wound healing materials, to drugs delivery systems and, increasingly also, materials for cell therapies and tissue repair and engineering.[l, 2] Though, the use of polymers as an artificial extracellular matrix and a support for tissue regeneration promises exciting perspectives for medicine, at the same time, it also poses a major challenge to the fundamental science interfacing the polymer chemistry and cell biology. The materials sought as templates for implanted cells, or as a support for tissue regeneration, must fulfill rather complex requirements, among which two issues become increasingly important: (a) a controlled biodegradability of the polymer matrix, and (b) polymer-cell and/or polymer -tissue interactions.[l, 3] In the past decade, significant advances have been made in understanding the ways in which cells interact with their natural environment of extracellular-matrix proteins.[4] This knowledge has laid the foundation for the rational design of polymers that could play an active role in tissue regeneration and repair. New polymers and their supramolecular constructs, tailored to provoke a physiological response such as growth and differentiation of cells in a controlled way, are being sought. [5, 6]
Macromolecular Design of New Synthetic Biodegradable Medical Polymers
Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences
Rypáček, F. (author)
2002-01-01
16 pages
Article/Chapter (Book)
Electronic Resource
English
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