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Tissue-Engineered Vascular Grafts for Small-Diameter Arterial Replacement
Abstract The human blood circulation is a closed system of conduits that carries blood from the heart to all tissues, and from these tissues back to the heart. In this system, the aorta and other, smaller arteries distribute blood from the heart to the various parts of the body. A normal artery has a tube-like structure comprising of three distinctive layers: the intima, the media and the adventitia (figure 1). The intima, the inner layer of the artery that is in contact with blood, consists of a monolayer of endothelial cells supported by an underlying connective tissue membrane. The media comprises of e.g. collagene and elastin, with a dense population of smooth muscle cells (SMCs) that are oriented perpendicular to the blood flow. The adventitia, the outer layer of the artery, is a collagenous matrix containing fibroblasts, small blood vessels and nerves.
Tissue-Engineered Vascular Grafts for Small-Diameter Arterial Replacement
Abstract The human blood circulation is a closed system of conduits that carries blood from the heart to all tissues, and from these tissues back to the heart. In this system, the aorta and other, smaller arteries distribute blood from the heart to the various parts of the body. A normal artery has a tube-like structure comprising of three distinctive layers: the intima, the media and the adventitia (figure 1). The intima, the inner layer of the artery that is in contact with blood, consists of a monolayer of endothelial cells supported by an underlying connective tissue membrane. The media comprises of e.g. collagene and elastin, with a dense population of smooth muscle cells (SMCs) that are oriented perpendicular to the blood flow. The adventitia, the outer layer of the artery, is a collagenous matrix containing fibroblasts, small blood vessels and nerves.
Tissue-Engineered Vascular Grafts for Small-Diameter Arterial Replacement
Wissink, M. J. B. (author) / Feijen, J. (author)
2002-01-01
15 pages
Article/Chapter (Book)
Electronic Resource
English
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