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A platform for research: civil engineering, architecture and urbanism
Preparation and Characterization of Nateglinide Loaded Hydrophobic Biocompatible Polymer Nanoparticles
Abstract The aim of the present study was to develop sustained release Nateglinide loaded Ethylcellulose nanoparticles and characterize the properties of recovered nanoparticles. The sustained release nanoparticles were prepared by oil in water single emulsion solvent evaporation method. The developed nanoparticles were characterised for their particle size, morphology, encapsulation efficiency, drug polymer compatibility and in vitro drug release. The drug polymer compatibility was investigated by XRPD. Imaging of particles was performed by field emission scanning electron microscopy. The highest particle size and encapsulation efficiency of recovered nanoparticles were 248.37 nm and 91.16 % respectively. The recovered nanoparticles are spherical in nature and uniform in size. Developed nanoparticles have low crystallinity than the pure Nateglinide. The highest drug-polymer ratio formulation showed drug release 61.1 ± 1.76 % up to 24 h.
Preparation and Characterization of Nateglinide Loaded Hydrophobic Biocompatible Polymer Nanoparticles
Abstract The aim of the present study was to develop sustained release Nateglinide loaded Ethylcellulose nanoparticles and characterize the properties of recovered nanoparticles. The sustained release nanoparticles were prepared by oil in water single emulsion solvent evaporation method. The developed nanoparticles were characterised for their particle size, morphology, encapsulation efficiency, drug polymer compatibility and in vitro drug release. The drug polymer compatibility was investigated by XRPD. Imaging of particles was performed by field emission scanning electron microscopy. The highest particle size and encapsulation efficiency of recovered nanoparticles were 248.37 nm and 91.16 % respectively. The recovered nanoparticles are spherical in nature and uniform in size. Developed nanoparticles have low crystallinity than the pure Nateglinide. The highest drug-polymer ratio formulation showed drug release 61.1 ± 1.76 % up to 24 h.
Preparation and Characterization of Nateglinide Loaded Hydrophobic Biocompatible Polymer Nanoparticles
Naik, Jitendra (author) / Lokhande, Amolkumar (author) / Mishra, Satyendra (author) / Kulkarni, Ravindra (author)
Journal of The Institution of Engineers (India): Series D ; 98 ; 269-277
2016-09-12
9 pages
Article (Journal)
Electronic Resource
English
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