A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Cadmium, Cellular Senescence, and Cancer
https://orcid.org/https://orcid.org/0000-0001-5795-2449
https://orcid.org/https://orcid.org/0000-0003-2528-8787
https://orcid.org/https://orcid.org/0000-0003-1124-0045
https://orcid.org/https://orcid.org/0000-0002-7146-7789
Cadmium (Cd) is an environmentally widespread toxic heavy metal with adverse effects on human health. Exposure to Cd is almost unavoidable in the modern-day world, and humans are most commonly exposed to Cd via contaminated food and drinking water, occupational inhalation, and cigarette smoking. Cellular senescence is characterized by the acquisition of senescence-associated secretory phenotype (SASP) and permanent cell cycle arrest, which is triggered by various types of stresses. Depending on the physiological context, cellular senescence can be beneficial or detrimental. In regard to cancer, senescence is a potent tumor suppressor mechanism, but on the other hand, it paradoxically fuels tumorigenesis. Based on the known mechanism of action of Cd, it is likely that Cd exposure is involved in cellular senescence and aging-related tumorigenesis. Here, we summarize and discuss the current knowledge regarding the interconnected relationships between Cd exposure, senescence, and cancer from three main aspects of Cd toxicity that have not been focused on previously: micronutrient homeostasis, SASP, and telomere length. This review encourages further investigation into the emergent research theme of Cd cytotoxicity.
Cadmium, Cellular Senescence, and Cancer
https://orcid.org/https://orcid.org/0000-0001-5795-2449
https://orcid.org/https://orcid.org/0000-0003-2528-8787
https://orcid.org/https://orcid.org/0000-0003-1124-0045
https://orcid.org/https://orcid.org/0000-0002-7146-7789
Cadmium (Cd) is an environmentally widespread toxic heavy metal with adverse effects on human health. Exposure to Cd is almost unavoidable in the modern-day world, and humans are most commonly exposed to Cd via contaminated food and drinking water, occupational inhalation, and cigarette smoking. Cellular senescence is characterized by the acquisition of senescence-associated secretory phenotype (SASP) and permanent cell cycle arrest, which is triggered by various types of stresses. Depending on the physiological context, cellular senescence can be beneficial or detrimental. In regard to cancer, senescence is a potent tumor suppressor mechanism, but on the other hand, it paradoxically fuels tumorigenesis. Based on the known mechanism of action of Cd, it is likely that Cd exposure is involved in cellular senescence and aging-related tumorigenesis. Here, we summarize and discuss the current knowledge regarding the interconnected relationships between Cd exposure, senescence, and cancer from three main aspects of Cd toxicity that have not been focused on previously: micronutrient homeostasis, SASP, and telomere length. This review encourages further investigation into the emergent research theme of Cd cytotoxicity.
Cadmium, Cellular Senescence, and Cancer
https://orcid.org/https://orcid.org/0000-0001-5795-2449
https://orcid.org/https://orcid.org/0000-0003-2528-8787
https://orcid.org/https://orcid.org/0000-0003-1124-0045
https://orcid.org/https://orcid.org/0000-0002-7146-7789
Cadmium (Cd) is an environmentally widespread toxic heavy metal with adverse effects on human health. Exposure to Cd is almost unavoidable in the modern-day world, and humans are most commonly exposed to Cd via contaminated food and drinking water, occupational inhalation, and cigarette smoking. Cellular senescence is characterized by the acquisition of senescence-associated secretory phenotype (SASP) and permanent cell cycle arrest, which is triggered by various types of stresses. Depending on the physiological context, cellular senescence can be beneficial or detrimental. In regard to cancer, senescence is a potent tumor suppressor mechanism, but on the other hand, it paradoxically fuels tumorigenesis. Based on the known mechanism of action of Cd, it is likely that Cd exposure is involved in cellular senescence and aging-related tumorigenesis. Here, we summarize and discuss the current knowledge regarding the interconnected relationships between Cd exposure, senescence, and cancer from three main aspects of Cd toxicity that have not been focused on previously: micronutrient homeostasis, SASP, and telomere length. This review encourages further investigation into the emergent research theme of Cd cytotoxicity.
Cadmium, Cellular Senescence, and Cancer
Reviews Env.Contamination (formerly:Residue Reviews)
Tan, Heng Wee (author) / Seen, Daniel L. T. (author) / Xu, Yan-Ming (author) / Lau, Andy T. Y. (author)
2023-12-01
Article (Journal)
Electronic Resource
English
Cellular Senescence, Neurological Function, and Redox State
| British Library Online Contents | 2018
Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration
| British Library Online Contents | 2018
Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?
| British Library Online Contents | 2008
ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway
| British Library Online Contents | 2015