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Mechanical and chemical properties of the injectable calcium phosphate cement
New calcium phosphate cement has been developed. The powder component is a mixture of alpha-tricalcium phosphate, tetracalcium phosphate and calcium hydrogen phosphate dihydrate, while the liquid is an aqueous solution containing sodium succinate and sodium chondroitin sulfate. An injectable paste or a hand-shapeable dough can be prepared by manually mixing the two components for a minute with proper powder to liquid ratio (P/L=2.0 to 4.5). The mixture can mostly set within about 6 minutes after mixing at 37 deg C in humid atmosphere, although the setting time is dependent on the P/L and the environmental temperature during the mixing process. The mixture also sets in the simulated body fluid without severe change in pH and gradually turns into low crystalline carbonated hydroxyapatite that can be slowly substituted by bone in vivo. Compressive strength of the cured material is about 65MPa in 3 days after mixing, and reaches its final strength more than 70 MPa in a week. Elastic modulus of the hardened body is about 4.5 GPa. This is slightly higher than porous hydroxyapatite implants. These strength and biocompatibility as well as less invasive surgical process by injection of this new cement will bring many opportunities to be applied at fracture fixation, filling bone defect and intensification of bone.
Mechanical and chemical properties of the injectable calcium phosphate cement
New calcium phosphate cement has been developed. The powder component is a mixture of alpha-tricalcium phosphate, tetracalcium phosphate and calcium hydrogen phosphate dihydrate, while the liquid is an aqueous solution containing sodium succinate and sodium chondroitin sulfate. An injectable paste or a hand-shapeable dough can be prepared by manually mixing the two components for a minute with proper powder to liquid ratio (P/L=2.0 to 4.5). The mixture can mostly set within about 6 minutes after mixing at 37 deg C in humid atmosphere, although the setting time is dependent on the P/L and the environmental temperature during the mixing process. The mixture also sets in the simulated body fluid without severe change in pH and gradually turns into low crystalline carbonated hydroxyapatite that can be slowly substituted by bone in vivo. Compressive strength of the cured material is about 65MPa in 3 days after mixing, and reaches its final strength more than 70 MPa in a week. Elastic modulus of the hardened body is about 4.5 GPa. This is slightly higher than porous hydroxyapatite implants. These strength and biocompatibility as well as less invasive surgical process by injection of this new cement will bring many opportunities to be applied at fracture fixation, filling bone defect and intensification of bone.
Mechanical and chemical properties of the injectable calcium phosphate cement
Mechanische und chemische Eigenschaften von spritzbarem Calciumphosphatzement
Asaoka, N. (author) / Misago, M. (author) / Hirano, M. (author) / Takeuchi, H. (author)
1999
4 Seiten, 6 Bilder, 10 Quellen
Conference paper
English
mechanische Eigenschaft , chemische Eigenschaft , Zement , hydraulischer Zement , Knochenzement , Calciumphosphat , Abbindung , Erhärten (Zementabbinden) , Körperflüssigkeit , Druckfestigkeit , Elastizitätsmodul , Temperatureinfluss , Wasser-Zement-Wert , Phosphat , Calciumphosphathydrat , Tricalciumphosphat , Phosphatbinder , Spritzen , Injektion , Probeninjektion , Biomaterial , Bioverträglichkeit
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