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A platform for research: civil engineering, architecture and urbanism
Synthesis of bioactive PMMA bone cement via modification with alkoxysilane and calcium salt; effect of calcium salt
Bone cement consisting of polymethylmethacrylate (PMMA) powder and methylmethacrylate (MMA) liquid is clinically used for fixation of implants such as artificial hip joint. However it does not show bone-bonding ability, i.e. bioactivity. The present authors recently developed bioactive PMMA-based bone cement through modification with 3methacryloxypropyltrimethpoxysilane (MPS) and calcium salts. In this study, effects of kinds of calcium salts on apatite formation and compressive strength were investigated in a simulated body fluid (Kokubo solution). The cement modified with CaCl2 and Ca(CH3COO)2 formed apatite within 3 days in Kokubo solution, and that modified with Ca(OH)2 within 7 days. Compressive strength of the modified cements after soaked in Kokubo solution was increased in the order CaCl2 < Ca(CH3COO3)2 < Ca(OH)2. These results indicate that PMMA cement can be provided with bioactivity without appreciably degrading its mechanical properties, when rate of the release of Ca(2+) ions from the cement into body fluid is controlled by appropriate selection of calcium salts.
Synthesis of bioactive PMMA bone cement via modification with alkoxysilane and calcium salt; effect of calcium salt
Bone cement consisting of polymethylmethacrylate (PMMA) powder and methylmethacrylate (MMA) liquid is clinically used for fixation of implants such as artificial hip joint. However it does not show bone-bonding ability, i.e. bioactivity. The present authors recently developed bioactive PMMA-based bone cement through modification with 3methacryloxypropyltrimethpoxysilane (MPS) and calcium salts. In this study, effects of kinds of calcium salts on apatite formation and compressive strength were investigated in a simulated body fluid (Kokubo solution). The cement modified with CaCl2 and Ca(CH3COO)2 formed apatite within 3 days in Kokubo solution, and that modified with Ca(OH)2 within 7 days. Compressive strength of the modified cements after soaked in Kokubo solution was increased in the order CaCl2 < Ca(CH3COO3)2 < Ca(OH)2. These results indicate that PMMA cement can be provided with bioactivity without appreciably degrading its mechanical properties, when rate of the release of Ca(2+) ions from the cement into body fluid is controlled by appropriate selection of calcium salts.
Synthesis of bioactive PMMA bone cement via modification with alkoxysilane and calcium salt; effect of calcium salt
Synthese von bioaktivem PMMA Knochenzement durch Modifikationen mit Alkoxysilanen und Calziumsalzen sowie ein Vergleich mit auf dem Markt befindlichen Knochenzementen auf Calciumphosphatbasis
Ohtsuki, C. (author) / Kyomoto, M. (author) / Miyazaki, T. (author) / Tanihara, M. (author) / Mori, A. (author) / Kuramoto, K. (author)
2002
5 Seiten, 4 Bilder, 2 Tabellen, 6 Quellen
Conference paper
English
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