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The in vitro antibiotic release from anti-washout apatite cement using chitosan
The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10 %. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-ACwas immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10 % flomoxef sodium (0 % vs. 10 %) was not significant (p > 0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8 % or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, the authors conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.
The in vitro antibiotic release from anti-washout apatite cement using chitosan
The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10 %. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-ACwas immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10 % flomoxef sodium (0 % vs. 10 %) was not significant (p > 0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8 % or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, the authors conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.
The in vitro antibiotic release from anti-washout apatite cement using chitosan
In vitro-Freisetzung von Antibiotika aus einem Apatitzement vom Anti-Auswasch-Typ mit Hilfe von Chitosan
Takechi, M. (author) / Miyamoto, Y. (author) / Momota, y. (author) / Yuasa, T. (author) / Tatehara, S. (author) / Nagayama, M. (author) / Ishikawa, K. (author) / Suzuki, K. (author)
Journal of Materials Science - Materials in Medicine ; 13 ; 973-978
2002
6 Seiten, 3 Bilder, 1 Tabelle, 51 Quellen
Article (Journal)
English
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