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Alumina powder / PMMA composite cements: an evaluation of osteoconductivity
New composites consisting of high molecular weight polymethyl methacrylate (hPMMA) and delta- or alpha-alumina powder (designated deltaAPC and alphaAPC, respectively), which allow direct bone formation on their surfaces in vivo, have been developed. Especially, delta-APC allowed much more bone formation on the surface. delta-Alumina powder was manufactured by fusing pulverized alumina powder and quenching it. It was composed mainly of delta -crystal phases of alumina. The purpose of the present study was to evaluate osteoconductivity of these composites. The hPMMA itself was used as a reference material. These three types of composites were packed into the intramedullary canals of rat tibiae to evaluate osteoconductivity , as determined by an affinity index. Rats were sacrificed at 4 and 8 weeks after surgery . The affinity index, equal to the length of bone in direct contact with the composite surface expressed as a percentage of the total length of the composite surface, was calculated for each composite at each interval. Histologically, new bone bad formed along the surface of both delta-APC and alphaAPC within 4 weeks. The affinity indices for hoth deltaAPC and alphaAPC increased significantly with time up to 8 weeks. At 8 weeks, the affinity index for deltaAPC was significantly higher than those for alphaAPC and hPMMA. This study revealed that the excellent osteoconductivity of deltaAPC was due to the alumina's delta -crystal phases and the high molecular weight of hPMMA. deltaAPC sbows promise as a basis for developing a highly osteoconductive biomaterial.
Alumina powder / PMMA composite cements: an evaluation of osteoconductivity
New composites consisting of high molecular weight polymethyl methacrylate (hPMMA) and delta- or alpha-alumina powder (designated deltaAPC and alphaAPC, respectively), which allow direct bone formation on their surfaces in vivo, have been developed. Especially, delta-APC allowed much more bone formation on the surface. delta-Alumina powder was manufactured by fusing pulverized alumina powder and quenching it. It was composed mainly of delta -crystal phases of alumina. The purpose of the present study was to evaluate osteoconductivity of these composites. The hPMMA itself was used as a reference material. These three types of composites were packed into the intramedullary canals of rat tibiae to evaluate osteoconductivity , as determined by an affinity index. Rats were sacrificed at 4 and 8 weeks after surgery . The affinity index, equal to the length of bone in direct contact with the composite surface expressed as a percentage of the total length of the composite surface, was calculated for each composite at each interval. Histologically, new bone bad formed along the surface of both delta-APC and alphaAPC within 4 weeks. The affinity indices for hoth deltaAPC and alphaAPC increased significantly with time up to 8 weeks. At 8 weeks, the affinity index for deltaAPC was significantly higher than those for alphaAPC and hPMMA. This study revealed that the excellent osteoconductivity of deltaAPC was due to the alumina's delta -crystal phases and the high molecular weight of hPMMA. deltaAPC sbows promise as a basis for developing a highly osteoconductive biomaterial.
Alumina powder / PMMA composite cements: an evaluation of osteoconductivity
Shinzato, S. (author) / Nakamura, T. (author) / Kokubo, T. (author)
2003
4 Seiten, 1 Bild, 12 Quellen
Conference paper
English
Alumina Powder/PMMA Composite Cements: An Evaluation of Osteoconductivity
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