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Bioactive bone cements containing micron-sized titania particles

Goto, K. / Hashimoto, M. / Takadama, H. / Tamura, J. / Fujibayashi, S. / Hasegawa, S. / Kawanabe, K. / Kokubo, T. / Nakamura, T.

Three types of polymethylmethacrylate (PMMA)-based composite cements containing 40 - 56 wt-% micron-sized titania (titanium oxide) particles, designated ST2-40c, ST2-50c, and ST2-56c, were developed as bone substitutes for vertebroplasty, and evaluated for their mechanical, setting, and biological properties. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. Their biological properties were evaluated at 6 and 12 weeks after implantation. Compressive strength, bending strength, and bending modulus increased with increasing titania content. Peak temperature during the setting reaction decreased as the filler content increased. ST2-56c had direct contact with bone over larger areas than ST2-50c at 6 and 12 weeks. Data from the present study indicated that ST2-56c is a good candidate as a bone substitute for vertebroplasty.

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Bioactive bone cements containing micron-sized titania particles

Goto, K. / Hashimoto, M. / Takadama, H. / Tamura, J. / Fujibayashi, S. / Hasegawa, S. / Kawanabe, K. / Kokubo, T. / Nakamura, T.

Three types of polymethylmethacrylate (PMMA)-based composite cements containing 40 - 56 wt-% micron-sized titania (titanium oxide) particles, designated ST2-40c, ST2-50c, and ST2-56c, were developed as bone substitutes for vertebroplasty, and evaluated for their mechanical, setting, and biological properties. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. Their biological properties were evaluated at 6 and 12 weeks after implantation. Compressive strength, bending strength, and bending modulus increased with increasing titania content. Peak temperature during the setting reaction decreased as the filler content increased. ST2-56c had direct contact with bone over larger areas than ST2-50c at 6 and 12 weeks. Data from the present study indicated that ST2-56c is a good candidate as a bone substitute for vertebroplasty.

Bioactive bone cements containing micron-sized titania particles

Goto, K. / Hashimoto, M. / Takadama, H. / Tamura, J. / Fujibayashi, S. / Hasegawa, S. / Kawanabe, K. / Kokubo, T. / Nakamura, T.

Three types of polymethylmethacrylate (PMMA)-based composite cements containing 40 - 56 wt-% micron-sized titania (titanium oxide) particles, designated ST2-40c, ST2-50c, and ST2-56c, were developed as bone substitutes for vertebroplasty, and evaluated for their mechanical, setting, and biological properties. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. Their biological properties were evaluated at 6 and 12 weeks after implantation. Compressive strength, bending strength, and bending modulus increased with increasing titania content. Peak temperature during the setting reaction decreased as the filler content increased. ST2-56c had direct contact with bone over larger areas than ST2-50c at 6 and 12 weeks. Data from the present study indicated that ST2-56c is a good candidate as a bone substitute for vertebroplasty.

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Title:

Bioactive bone cements containing micron-sized titania particles

Contributors:

Goto, K. (author) / Hashimoto, M. (author) / Takadama, H. (author) / Tamura, J. (author) / Fujibayashi, S. (author) / Hasegawa, S. (author) / Kawanabe, K. (author) / Kokubo, T. (author) / Nakamura, T. (author)

Published in:

Bioceramics 18, ISCM, International Symposium on Ceramics in Medicine, the Annual Meeting of the International Society for Ceramics in Medicine, 18 ; 793-796

Key Engineering Materials ; 309-311

Publication date:

2006

Size:

4 Seiten, 2 Bilder, 3 Tabellen, 3 Quellen

ISBN:

ISSN:

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.793

Type of media:

Conference paper

Type of material:

Print

Language:

English

Keywords:

Anatas , Anwendung in der Medizin , Biegefestigkeit , Bioaktivität , Biokompatibilität , biologische Eigenschaft , Druckfestigkeit , Füllstoff , Knochenleitfähigkeit , Knochenzement , mechanische Eigenschaft , Mikropartikel , Polymethylmethacrylat , Rutil , Tierversuch , Titanoxid , Verbundstoff , Vertebroplastik

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