A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
24 months inhalation carclnogeniclty study of bitumen fumes in wistar (WU) rats
The objective of this study was to evaluate the possible carcinogenic effect of Bitumen fumes, produced under conditions similar to road paving, after a 24-month inhalation in rats. Animal studies have shown that the inhalation studies in rats are a suitable experimental model for investigating PAH (polycyclic aromatic compound) mediated carcinogenicity and produce similar tumor rates comparable to that observed in man. Based on the results of a 13-Week Study 4, 20, and 100 mg/m3 THC (Total Hydrocarbons) were chosen as the concentrations for the low, medium, and high dose groups. Data collected by the German Bitumen Forum indicated exposure to bitumen vapor and aerosol during road paving for the paver operator (2.8 mg/m3), the screen operator (3.8 mg/m3), and the roller driver (1.3 mg/m3). Therefore the factor between workers' exposure at road paving and our exposure conditions was about 1,5, and 25 for the low, medium, and high dose groups, respectively. In separate publications the collection, validation and generation of fumes originating from heated bitumen used in this study were recently published. (For the current study, a laboratory generated exposure atmosphere was developed that resembles as closely as possible personal exposures of workers during road paving operations regarding boiling point distribution, UV fluorescence, and content of individual PAHs. To achieve this objective, atmospheric workplace samples were collected at road paving worksites and compared analytically with bitumen fume samples collected from the headspace of hot bitumen storage tanks. It was demonstrated that it is possible to develop a collecting procedure that allows sampling from hot bitumen storage tanks in an operational asphalt mixing plant. The sampling procedure has been optimized to collect material that matches the workplace samples as closely as possible. The comparison to workplace samples has been performed using parameters that could be analyzed in both the workplace samples and the bitumen fume condensate collected from the tanks.
24 months inhalation carclnogeniclty study of bitumen fumes in wistar (WU) rats
The objective of this study was to evaluate the possible carcinogenic effect of Bitumen fumes, produced under conditions similar to road paving, after a 24-month inhalation in rats. Animal studies have shown that the inhalation studies in rats are a suitable experimental model for investigating PAH (polycyclic aromatic compound) mediated carcinogenicity and produce similar tumor rates comparable to that observed in man. Based on the results of a 13-Week Study 4, 20, and 100 mg/m3 THC (Total Hydrocarbons) were chosen as the concentrations for the low, medium, and high dose groups. Data collected by the German Bitumen Forum indicated exposure to bitumen vapor and aerosol during road paving for the paver operator (2.8 mg/m3), the screen operator (3.8 mg/m3), and the roller driver (1.3 mg/m3). Therefore the factor between workers' exposure at road paving and our exposure conditions was about 1,5, and 25 for the low, medium, and high dose groups, respectively. In separate publications the collection, validation and generation of fumes originating from heated bitumen used in this study were recently published. (For the current study, a laboratory generated exposure atmosphere was developed that resembles as closely as possible personal exposures of workers during road paving operations regarding boiling point distribution, UV fluorescence, and content of individual PAHs. To achieve this objective, atmospheric workplace samples were collected at road paving worksites and compared analytically with bitumen fume samples collected from the headspace of hot bitumen storage tanks. It was demonstrated that it is possible to develop a collecting procedure that allows sampling from hot bitumen storage tanks in an operational asphalt mixing plant. The sampling procedure has been optimized to collect material that matches the workplace samples as closely as possible. The comparison to workplace samples has been performed using parameters that could be analyzed in both the workplace samples and the bitumen fume condensate collected from the tanks.
24 months inhalation carclnogeniclty study of bitumen fumes in wistar (WU) rats
Eine Untersuchung der Karzinogenität einer 24-monatigen Inhalation von Bitumendämpfen mit Wistar-Ratten
Fuhst, Rainer (author) / Creutzenberg, Otto (author) / Ernst, Heinrich (author) / Hansen, Tanja (author) / Pohlmann, Gerhard (author) / Preiss, Alfred (author) / Rittinghausen, Susanne (author)
2007
24 Seiten, 15 Bilder, 14 Tabellen, 36 Quellen
Conference paper
English
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