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Hydration Dependent Viscoelastic Tensile Behavior of Cornea
The cornea is a protective transparent connective tissue covering the front of the eye. The standard uniaxial tensile experiments are among the most popular techniques for investigating biomechanical properties of the cornea. This experimental method characterizes the stress–strain response of corneal strips immersed in a bathing solution. In the present study, the important roles of corneal hydration on tensile viscoelastic properties were investigated. The thickness was used as a surrogate for hydration and uniaxial tensile experiments were performed on bovine corneal samples with four different average thickness (hydration), i.e., 1100 µm (4.87 mg water/mg dry tissue), 900 µm (4.13 mg water/mg dry tissue), 700 µm (3.20 mg water/mg dry tissue), and 500 µm (1.95 mg water/mg dry tissue). The samples were immersed in mineral oil in order to prevent their swelling during the experiments. A quasilinear viscoelastic (QLV) model was used to analyze the experimental measurements and determine viscoelastic material constants. It was observed that both maximum and equilibrium (relaxed) stresses were exponentially increased with decreasing tissue thickness (hydration). Furthermore, the QLV model successfully captured the corneal viscoelastic response with an average R2 value greater than 0.99. Additional experiments were conducted in OBSS in order to confirm that these significant changes in viscoelastic properties were because of corneal hydration and not the bathing solution. The findings of this study suggest that extra care must be taken in interpreting the results of earlier uniaxial tensile testings and their correspondence to the corneal biomechanical properties.
Hydration Dependent Viscoelastic Tensile Behavior of Cornea
The cornea is a protective transparent connective tissue covering the front of the eye. The standard uniaxial tensile experiments are among the most popular techniques for investigating biomechanical properties of the cornea. This experimental method characterizes the stress–strain response of corneal strips immersed in a bathing solution. In the present study, the important roles of corneal hydration on tensile viscoelastic properties were investigated. The thickness was used as a surrogate for hydration and uniaxial tensile experiments were performed on bovine corneal samples with four different average thickness (hydration), i.e., 1100 µm (4.87 mg water/mg dry tissue), 900 µm (4.13 mg water/mg dry tissue), 700 µm (3.20 mg water/mg dry tissue), and 500 µm (1.95 mg water/mg dry tissue). The samples were immersed in mineral oil in order to prevent their swelling during the experiments. A quasilinear viscoelastic (QLV) model was used to analyze the experimental measurements and determine viscoelastic material constants. It was observed that both maximum and equilibrium (relaxed) stresses were exponentially increased with decreasing tissue thickness (hydration). Furthermore, the QLV model successfully captured the corneal viscoelastic response with an average R2 value greater than 0.99. Additional experiments were conducted in OBSS in order to confirm that these significant changes in viscoelastic properties were because of corneal hydration and not the bathing solution. The findings of this study suggest that extra care must be taken in interpreting the results of earlier uniaxial tensile testings and their correspondence to the corneal biomechanical properties.
Hydration Dependent Viscoelastic Tensile Behavior of Cornea
Hatami-Marbini, Hamed (author)
Annals of Biomedical Engineering ; 42 ; 1740-1748
2014
9 Seiten
Article (Journal)
English
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