A platform for research: civil engineering, architecture and urbanism
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Impact of Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis and Intestinal Failure
Objective To examine the microbiology and outcomes related to bloodstream infections (BSIs) in neonates with intestinal failure (IF) due to necrotizing enterocolitis (NEC).Study Design I performed a retrospective review of very low birth weight (VLBW) neonates with late-onset BSI at a single center over 8.5 years. Recurrence and frequencies of BSI pathogens were compared between neonates with and without IF. Pathogen frequencies and mortality were compared for NEC-associated BSI (≤72 hours from NEC diagnosis) and post-NEC BSI (>72 hours after NEC diagnosis) in neonates with and without IF. Results 177 neonates with 234 BSIs were studied. Compared to other VLBW neonates with BSI, IF patients (n=45) suffered more often from recurrent BSI (44% vs. 20%, p=0.01), and frequently had gut-bacteria BSI (51% vs. 28%, p=0.01). NEC-associated BSIs in IF patients had similar pathogen profiles to BSIs in other VLWB neonates, while post-NEC BSIs in IF patients were more commonly due to gut bacteria (48% vs. 23%, p<0.00). Mortality for IF patients with post-NEC BSI was the same as for the cohort as a whole (17%). IF patients with NEC-associated BSI had higher odds of death (OR 3.9) than other neonates (35% vs. 15%, p=0.02).Conclusions IF patients commonly have recurrent BSI and gut-bacteria BSI. The microbiologic etiology of post-NEC BSI in neonates with IF is different from BSI in other VLBW neonates, and is more commonly of gut origin. IF patients with NEC-associated BSI have a significantly higher odds of death than other VLBW neonates with BSI.
Impact of Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis and Intestinal Failure
Objective To examine the microbiology and outcomes related to bloodstream infections (BSIs) in neonates with intestinal failure (IF) due to necrotizing enterocolitis (NEC).Study Design I performed a retrospective review of very low birth weight (VLBW) neonates with late-onset BSI at a single center over 8.5 years. Recurrence and frequencies of BSI pathogens were compared between neonates with and without IF. Pathogen frequencies and mortality were compared for NEC-associated BSI (≤72 hours from NEC diagnosis) and post-NEC BSI (>72 hours after NEC diagnosis) in neonates with and without IF. Results 177 neonates with 234 BSIs were studied. Compared to other VLBW neonates with BSI, IF patients (n=45) suffered more often from recurrent BSI (44% vs. 20%, p=0.01), and frequently had gut-bacteria BSI (51% vs. 28%, p=0.01). NEC-associated BSIs in IF patients had similar pathogen profiles to BSIs in other VLWB neonates, while post-NEC BSIs in IF patients were more commonly due to gut bacteria (48% vs. 23%, p<0.00). Mortality for IF patients with post-NEC BSI was the same as for the cohort as a whole (17%). IF patients with NEC-associated BSI had higher odds of death (OR 3.9) than other neonates (35% vs. 15%, p=0.02).Conclusions IF patients commonly have recurrent BSI and gut-bacteria BSI. The microbiologic etiology of post-NEC BSI in neonates with IF is different from BSI in other VLBW neonates, and is more commonly of gut origin. IF patients with NEC-associated BSI have a significantly higher odds of death than other VLBW neonates with BSI.
Impact of Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis and Intestinal Failure
Smith, Siobhan Poling (author)
2015
Theses
Electronic Resource
English
Cerebral and splanchnic oxygenation and necrotizing enterocolitis in preterm infants
| BASE | 2015