A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization
https://orcid.org/0000-0001-5456-984X
AbstractThe left atrial appendage (LAA) occluder is an important medical device for closing the LAA and preventing stroke. The device‐related thrombus (DRT) prevents the implantation of the occluder in exerting the desired therapeutic effect, which is primarily caused by the delayed endothelialization of the occluder. Functional coatings are an effective strategy for accelerating the endothelialization of occluders. However, the occluder surface area is particularly large and structurally complex, and the device is subjected to a large shear friction in the sheath during implantation, which poses a significant challenge to the coating. Herein, a hydrogel coating by the in situ UV‐triggered polymerization of double‐network polyelectrolytes is reported. The findings reveal that the double network and electrostatic interactions between the networks resulted in excellent mechanical properties of the hydrogel coating. The sulfonate and Arg‐Gly‐Asp (RGD) groups in the coating promoted hemocompatibility and endothelial growth of the occluder, respectively. The coating significantly accelerated the endothelialization of the LAA occluder in a canine model is further demonstrated. This study has potential clinical benefits in reducing both the incidence of DRT and the postoperative anticoagulant course for LAA closure.
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization
https://orcid.org/0000-0001-5456-984X
AbstractThe left atrial appendage (LAA) occluder is an important medical device for closing the LAA and preventing stroke. The device‐related thrombus (DRT) prevents the implantation of the occluder in exerting the desired therapeutic effect, which is primarily caused by the delayed endothelialization of the occluder. Functional coatings are an effective strategy for accelerating the endothelialization of occluders. However, the occluder surface area is particularly large and structurally complex, and the device is subjected to a large shear friction in the sheath during implantation, which poses a significant challenge to the coating. Herein, a hydrogel coating by the in situ UV‐triggered polymerization of double‐network polyelectrolytes is reported. The findings reveal that the double network and electrostatic interactions between the networks resulted in excellent mechanical properties of the hydrogel coating. The sulfonate and Arg‐Gly‐Asp (RGD) groups in the coating promoted hemocompatibility and endothelial growth of the occluder, respectively. The coating significantly accelerated the endothelialization of the LAA occluder in a canine model is further demonstrated. This study has potential clinical benefits in reducing both the incidence of DRT and the postoperative anticoagulant course for LAA closure.
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization
https://orcid.org/0000-0001-5456-984X
AbstractThe left atrial appendage (LAA) occluder is an important medical device for closing the LAA and preventing stroke. The device‐related thrombus (DRT) prevents the implantation of the occluder in exerting the desired therapeutic effect, which is primarily caused by the delayed endothelialization of the occluder. Functional coatings are an effective strategy for accelerating the endothelialization of occluders. However, the occluder surface area is particularly large and structurally complex, and the device is subjected to a large shear friction in the sheath during implantation, which poses a significant challenge to the coating. Herein, a hydrogel coating by the in situ UV‐triggered polymerization of double‐network polyelectrolytes is reported. The findings reveal that the double network and electrostatic interactions between the networks resulted in excellent mechanical properties of the hydrogel coating. The sulfonate and Arg‐Gly‐Asp (RGD) groups in the coating promoted hemocompatibility and endothelial growth of the occluder, respectively. The coating significantly accelerated the endothelialization of the LAA occluder in a canine model is further demonstrated. This study has potential clinical benefits in reducing both the incidence of DRT and the postoperative anticoagulant course for LAA closure.
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization
Advanced Science
Wang, Xing‐wang (author) / Yin, Yi‐jing (author) / Wang, Jing (author) / Yu, Hong‐mei (author) / Tang, Qian (author) / Chen, Zhao‐yang (author) / Fu, Guo‐sheng (author) / Ren, Ke‐feng (author) / Ji, Jian (author) / Yu, Lu (author)
Advanced Science ; 11
2024-06-01
Article (Journal)
Electronic Resource
English
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization
| Wiley | 2024
Endothelialization of Titanium Surfaces
| British Library Online Contents | 2007
Nitride coating enhances endothelialization on biomedical NiTi shape memory alloy
| British Library Online Contents | 2016
| British Library Online Contents | 2012
Acid‐Triggered Dual‐Functional Hydrogel Platform for Enhanced Bone Regeneration
| Wiley | 2025