A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer
https://orcid.org/0000-0002-4460-1743
https://orcid.org/0009-0003-4824-8259
https://orcid.org/0000-0002-3178-1466
AbstractA significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy of pre‐existing antiviral immunity in tumor treatment is limited by the absence of corresponding targets. This study develops a novel platform of antigen‐targeted inserted nanomicelles, preS1 (an antigen of hepatitis B virus)‐pHLIP nanomicelles, in which tumor‐targeting nanomicelles release antigens that label tumor tissue for pre‐existing immunity‐mediated lysis in situ. In animal models of head and neck cancers, including head and neck squamous cell carcinoma and anaplastic thyroid cancer, preS1‐pHLIP nanomicelles effectively inhibited tumor growth, recurrence, and metastasis in animals pre‐immunized with preS1. This therapeutic effect is associated with an increase in the proportion of preS1‐specific B cells and activated tumor‐specific T cells within the tumor microenvironment. Overall, this work has engineered a nanomicelle that can disguise tumor cells as viruses and achieve tumor killing through the pre‐existing antiviral immune response. This strategy presents a novel approach for treating tumors with ambiguous therapeutic target profiles.
Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer
https://orcid.org/0000-0002-4460-1743
https://orcid.org/0009-0003-4824-8259
https://orcid.org/0000-0002-3178-1466
AbstractA significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy of pre‐existing antiviral immunity in tumor treatment is limited by the absence of corresponding targets. This study develops a novel platform of antigen‐targeted inserted nanomicelles, preS1 (an antigen of hepatitis B virus)‐pHLIP nanomicelles, in which tumor‐targeting nanomicelles release antigens that label tumor tissue for pre‐existing immunity‐mediated lysis in situ. In animal models of head and neck cancers, including head and neck squamous cell carcinoma and anaplastic thyroid cancer, preS1‐pHLIP nanomicelles effectively inhibited tumor growth, recurrence, and metastasis in animals pre‐immunized with preS1. This therapeutic effect is associated with an increase in the proportion of preS1‐specific B cells and activated tumor‐specific T cells within the tumor microenvironment. Overall, this work has engineered a nanomicelle that can disguise tumor cells as viruses and achieve tumor killing through the pre‐existing antiviral immune response. This strategy presents a novel approach for treating tumors with ambiguous therapeutic target profiles.
Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer
https://orcid.org/0000-0002-4460-1743
https://orcid.org/0009-0003-4824-8259
https://orcid.org/0000-0002-3178-1466
AbstractA significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy of pre‐existing antiviral immunity in tumor treatment is limited by the absence of corresponding targets. This study develops a novel platform of antigen‐targeted inserted nanomicelles, preS1 (an antigen of hepatitis B virus)‐pHLIP nanomicelles, in which tumor‐targeting nanomicelles release antigens that label tumor tissue for pre‐existing immunity‐mediated lysis in situ. In animal models of head and neck cancers, including head and neck squamous cell carcinoma and anaplastic thyroid cancer, preS1‐pHLIP nanomicelles effectively inhibited tumor growth, recurrence, and metastasis in animals pre‐immunized with preS1. This therapeutic effect is associated with an increase in the proportion of preS1‐specific B cells and activated tumor‐specific T cells within the tumor microenvironment. Overall, this work has engineered a nanomicelle that can disguise tumor cells as viruses and achieve tumor killing through the pre‐existing antiviral immune response. This strategy presents a novel approach for treating tumors with ambiguous therapeutic target profiles.
Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer
Advanced Science
Zhang, Lizhuo (author) / Feng, Qingqing (author) / Zheng, Chuanming (author) / Li, Yuanqiang (author) / Ge, Xinyang (author) / Jin, Tiefeng (author) / Hu, Gaofeng (author) / Tan, Zhuo (author) / Wang, Jiafeng (author) / Xu, Jiajie (author)
2025-03-17
Article (Journal)
Electronic Resource
English
Tocopheryl pullulan-based self assembling nanomicelles for anti-cancer drug delivery
| British Library Online Contents | 2014
Targeting of the Glutathione, Thioredoxin, and Nrf2 Antioxidant Systems in Head and Neck Cancer
British Library Online Contents | 2017
GUIDE RODS ARE INSERTED BULGE SUPPRESSED ELASTOMERIC BEARING
| European Patent Office | 2015