A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
https://orcid.org/0000-0002-2709-1083
https://orcid.org/0009-0007-9576-3447
https://orcid.org/0000-0003-2575-5816
https://orcid.org/0000-0002-7480-4242
AbstractMulticellular organisms have hierarchical structures where multiple cells collectively form tissues with complex 3D architectures and exhibit higher‐order functions. Inspired by this, to date, multiple protocell models have been assembled to form tissue‐like structures termed prototissues. Despite recent advances in this research area, the programmed assembly of protocells into prototissue fibers with emergent functions still represents a significant challenge. The possibility of assembling prototissue fibers will open up a way to a novel type of prototissue subunit capable of hierarchical assembly into unprecedented soft functional materials with tunable architectures, modular and distributed functionalities. Herein, the first method to fabricate freestanding vesicle‐based prototissue fibers with controlled lengths and diameters is devised. Importantly, it is also shown that the fibers can be composed of different specialized modules that, for example, can endow the fiber with magnetotaxis capabilities, or that can work synergistically to take an input diffusible chemical signals and transduce it into a readable fluorescent output through a hosted enzyme cascade reaction. Overall, this research addresses an important challenge of prototissue engineering and will find important applications in 3D bio‐printing, tissue engineering, and soft robotics as next‐generation bioinspired materials.
Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
https://orcid.org/0000-0002-2709-1083
https://orcid.org/0009-0007-9576-3447
https://orcid.org/0000-0003-2575-5816
https://orcid.org/0000-0002-7480-4242
AbstractMulticellular organisms have hierarchical structures where multiple cells collectively form tissues with complex 3D architectures and exhibit higher‐order functions. Inspired by this, to date, multiple protocell models have been assembled to form tissue‐like structures termed prototissues. Despite recent advances in this research area, the programmed assembly of protocells into prototissue fibers with emergent functions still represents a significant challenge. The possibility of assembling prototissue fibers will open up a way to a novel type of prototissue subunit capable of hierarchical assembly into unprecedented soft functional materials with tunable architectures, modular and distributed functionalities. Herein, the first method to fabricate freestanding vesicle‐based prototissue fibers with controlled lengths and diameters is devised. Importantly, it is also shown that the fibers can be composed of different specialized modules that, for example, can endow the fiber with magnetotaxis capabilities, or that can work synergistically to take an input diffusible chemical signals and transduce it into a readable fluorescent output through a hosted enzyme cascade reaction. Overall, this research addresses an important challenge of prototissue engineering and will find important applications in 3D bio‐printing, tissue engineering, and soft robotics as next‐generation bioinspired materials.
Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
https://orcid.org/0000-0002-2709-1083
https://orcid.org/0009-0007-9576-3447
https://orcid.org/0000-0003-2575-5816
https://orcid.org/0000-0002-7480-4242
AbstractMulticellular organisms have hierarchical structures where multiple cells collectively form tissues with complex 3D architectures and exhibit higher‐order functions. Inspired by this, to date, multiple protocell models have been assembled to form tissue‐like structures termed prototissues. Despite recent advances in this research area, the programmed assembly of protocells into prototissue fibers with emergent functions still represents a significant challenge. The possibility of assembling prototissue fibers will open up a way to a novel type of prototissue subunit capable of hierarchical assembly into unprecedented soft functional materials with tunable architectures, modular and distributed functionalities. Herein, the first method to fabricate freestanding vesicle‐based prototissue fibers with controlled lengths and diameters is devised. Importantly, it is also shown that the fibers can be composed of different specialized modules that, for example, can endow the fiber with magnetotaxis capabilities, or that can work synergistically to take an input diffusible chemical signals and transduce it into a readable fluorescent output through a hosted enzyme cascade reaction. Overall, this research addresses an important challenge of prototissue engineering and will find important applications in 3D bio‐printing, tissue engineering, and soft robotics as next‐generation bioinspired materials.
Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
Advanced Science
Kojima, Tomoya (author) / Asakura, Kouichi (author) / Gobbo, Pierangelo (author) / Banno, Taisuke (author)
2025-02-10
Article (Journal)
Electronic Resource
English
Fabrication using `programmed' reactions
| British Library Online Contents | 2007
Fabrication of nanocomposite particles with superparamagnetic and luminescent functionalities
| British Library Online Contents | 2008
Obtaining ultimate functionalities in nanocomposites: Design, control, and fabrication
| British Library Online Contents | 2015
British Library Online Contents | 2007
Fabrication of tubular ZnO by vesicle–template fusion
| British Library Online Contents | 2007