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Effect of short‐time exposures to nickel and lead on brain monoamine oxidase fromDanio rerioandPoecilia reticulata
AbstractThe aim of this work was to verify, in two small size freshwater teleostsDanio rerioandPoecilia reticulata, the effects of short‐time exposures (24 and 72 h) to a sublethal dose (500 μg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme. The 24‐h treatment using both metals caused a strong reduction of MAO activity inD. reriobrain, whereas causing a slight MAO activity stimulation inP. reticulatabrain. The same treatment in both species did not affect the brain MAO mRNA production as showed by RT‐PCR. Extending the duration of treatment as far as 72 h, partly (D. rerio) or completely (P. reticulata) reversed the metal effects on brain MAO activity suggesting that mechanisms to neutralize the metals had been activated. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
Effect of short‐time exposures to nickel and lead on brain monoamine oxidase fromDanio rerioandPoecilia reticulata
AbstractThe aim of this work was to verify, in two small size freshwater teleostsDanio rerioandPoecilia reticulata, the effects of short‐time exposures (24 and 72 h) to a sublethal dose (500 μg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme. The 24‐h treatment using both metals caused a strong reduction of MAO activity inD. reriobrain, whereas causing a slight MAO activity stimulation inP. reticulatabrain. The same treatment in both species did not affect the brain MAO mRNA production as showed by RT‐PCR. Extending the duration of treatment as far as 72 h, partly (D. rerio) or completely (P. reticulata) reversed the metal effects on brain MAO activity suggesting that mechanisms to neutralize the metals had been activated. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
Effect of short‐time exposures to nickel and lead on brain monoamine oxidase fromDanio rerioandPoecilia reticulata
Environmental Toxicology
Senatori, Ornella (author) / Setini, Andrea (author) / Scirocco, Annunziata (author) / Nicotra, Antonietta (author)
Environmental Toxicology ; 24 ; 309-313
2009-06-01
Article (Journal)
Electronic Resource
English
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