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Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
https://orcid.org/0000-0002-6350-7429
AbstractAn unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine‐derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ester as a sacrificial reductant, the transformations between α‐substituted enones and cyanoazaarenes or 2‐(chloromethyl)azaaren‐1‐iums can proceed a tandem reduction, radical coupling, and enantioselective protonation process efficiently. Two classes of pharmaceutically important enantioenriched azaarene variants, which contain a synthetically versatile ketone‐substituted tertiary carbon stereocenter at the β‐ or γ‐position of the azaarenes, are synthesized with high yields and ees.
Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
https://orcid.org/0000-0002-6350-7429
AbstractAn unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine‐derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ester as a sacrificial reductant, the transformations between α‐substituted enones and cyanoazaarenes or 2‐(chloromethyl)azaaren‐1‐iums can proceed a tandem reduction, radical coupling, and enantioselective protonation process efficiently. Two classes of pharmaceutically important enantioenriched azaarene variants, which contain a synthetically versatile ketone‐substituted tertiary carbon stereocenter at the β‐ or γ‐position of the azaarenes, are synthesized with high yields and ees.
Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
https://orcid.org/0000-0002-6350-7429
AbstractAn unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine‐derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ester as a sacrificial reductant, the transformations between α‐substituted enones and cyanoazaarenes or 2‐(chloromethyl)azaaren‐1‐iums can proceed a tandem reduction, radical coupling, and enantioselective protonation process efficiently. Two classes of pharmaceutically important enantioenriched azaarene variants, which contain a synthetically versatile ketone‐substituted tertiary carbon stereocenter at the β‐ or γ‐position of the azaarenes, are synthesized with high yields and ees.
Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
Advanced Science
Kong, Manman (author) / Wang, Zhuoxi (author) / Ban, Xu (author) / Zhao, Xiaowei (author) / Yin, Yanli (author) / Zhang, Junmin (author) / Jiang, Zhiyong (author)
Advanced Science ; 11
2024-03-01
Article (Journal)
Electronic Resource
English
Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
| Wiley | 2024
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