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Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
https://orcid.org/0000-0002-4853-4330
https://orcid.org/0000-0002-8673-7374
https://orcid.org/0000-0002-8899-0138
https://orcid.org/0009-0000-2332-1040
https://orcid.org/0000-0002-7982-6483
https://orcid.org/0000-0003-0778-5640
AbstractAutodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and targeted delivery have hindered its clinical translation owing to the induction of adverse effects and cytotoxicity in healthy cells. In this study, a novel approach for auto‐initiated dynamic therapy by conjugating zwitterionic near‐infrared fluorophores to a cell‐penetrating peptide is proposed. This enables efficient cellular uptake and specific targeting of therapy to desired cells while avoiding off‐target uptake. The zwitterionic bioconjugate causes cancer‐specific toxicity following its internalization into the targeted cells, triggered by specific intracellular conditions in lysosomes. This innovative approach enables selective targeting of lysosomes in malignant cells while minimizing cytotoxic effects on normal cells. By targeting lysosomes, the method overcomes inherent risks and side effects associated with conventional cancer treatments, offering a selective and effective approach to cancer therapy.
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
https://orcid.org/0000-0002-4853-4330
https://orcid.org/0000-0002-8673-7374
https://orcid.org/0000-0002-8899-0138
https://orcid.org/0009-0000-2332-1040
https://orcid.org/0000-0002-7982-6483
https://orcid.org/0000-0003-0778-5640
AbstractAutodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and targeted delivery have hindered its clinical translation owing to the induction of adverse effects and cytotoxicity in healthy cells. In this study, a novel approach for auto‐initiated dynamic therapy by conjugating zwitterionic near‐infrared fluorophores to a cell‐penetrating peptide is proposed. This enables efficient cellular uptake and specific targeting of therapy to desired cells while avoiding off‐target uptake. The zwitterionic bioconjugate causes cancer‐specific toxicity following its internalization into the targeted cells, triggered by specific intracellular conditions in lysosomes. This innovative approach enables selective targeting of lysosomes in malignant cells while minimizing cytotoxic effects on normal cells. By targeting lysosomes, the method overcomes inherent risks and side effects associated with conventional cancer treatments, offering a selective and effective approach to cancer therapy.
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
https://orcid.org/0000-0002-4853-4330
https://orcid.org/0000-0002-8673-7374
https://orcid.org/0000-0002-8899-0138
https://orcid.org/0009-0000-2332-1040
https://orcid.org/0000-0002-7982-6483
https://orcid.org/0000-0003-0778-5640
AbstractAutodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and targeted delivery have hindered its clinical translation owing to the induction of adverse effects and cytotoxicity in healthy cells. In this study, a novel approach for auto‐initiated dynamic therapy by conjugating zwitterionic near‐infrared fluorophores to a cell‐penetrating peptide is proposed. This enables efficient cellular uptake and specific targeting of therapy to desired cells while avoiding off‐target uptake. The zwitterionic bioconjugate causes cancer‐specific toxicity following its internalization into the targeted cells, triggered by specific intracellular conditions in lysosomes. This innovative approach enables selective targeting of lysosomes in malignant cells while minimizing cytotoxic effects on normal cells. By targeting lysosomes, the method overcomes inherent risks and side effects associated with conventional cancer treatments, offering a selective and effective approach to cancer therapy.
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
Advanced Science
Raveendran, Athira (author) / Ser, Jinhui (author) / Park, Seung Hun (author) / Jang, Paul (author) / Choi, Hak Soo (author) / Cho, Hoonsung (author)
Advanced Science ; 11
2024-11-01
Article (Journal)
Electronic Resource
English
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
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