A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
https://orcid.org/0009-0006-2073-5233
https://orcid.org/0009-0002-1507-3600
AbstractBackgroundObservational studies have indicated that peripheral blood eosinophil count is elevated in individuals diagnosed with ulcerative colitis (UC) and correlates with the disease activity of UC. However, this conclusion contradicts with findings from other studies. Therefore, we employed Mendelian randomization (MR) method to assess the genetic link between eosinophil count and UC.MethodThis MR study utilized summary data from genome‐wide association studies (GWAS) on eosinophil count and UC. The main approach used for conducting MR analysis was the inverse variance weighted (IVW) method. Meta‐analysis of the IVW results was performed alongside multiple sensitivity analyses to confirm the robustness of the MR analysis results.ResultsThe IVW method unveiled a causal relationship between eosinophil count and UC (OR = 1.18, 95% CI: 1.04–1.33, p = .01) in the discovery cohort. This finding was further corroborated by the replication cohorts (OR = 1.16, 95% CI: 1.04–1.29, p = .01; OR = 1.12, 95% CI: 1.01–1.24, p = .03). The meta‐analysis indicated that the overall odds ratio (OR) for all studies was 1.15 (common effect model, 95% CI: 1.08–1.23, p < .01). Sensitivity analysis suggested the absence of heterogeneity and horizontal pleiotropy in all MR analyses.ConclusionBased on bidirectional two‐sample MR analysis, there is an indication that elevated eosinophil count may increase the risk of UC. However, potential confounding factors cannot be ruled out, and further research is necessary to explore how eosinophils contribute to the onset and progression of UC.
Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
https://orcid.org/0009-0006-2073-5233
https://orcid.org/0009-0002-1507-3600
AbstractBackgroundObservational studies have indicated that peripheral blood eosinophil count is elevated in individuals diagnosed with ulcerative colitis (UC) and correlates with the disease activity of UC. However, this conclusion contradicts with findings from other studies. Therefore, we employed Mendelian randomization (MR) method to assess the genetic link between eosinophil count and UC.MethodThis MR study utilized summary data from genome‐wide association studies (GWAS) on eosinophil count and UC. The main approach used for conducting MR analysis was the inverse variance weighted (IVW) method. Meta‐analysis of the IVW results was performed alongside multiple sensitivity analyses to confirm the robustness of the MR analysis results.ResultsThe IVW method unveiled a causal relationship between eosinophil count and UC (OR = 1.18, 95% CI: 1.04–1.33, p = .01) in the discovery cohort. This finding was further corroborated by the replication cohorts (OR = 1.16, 95% CI: 1.04–1.29, p = .01; OR = 1.12, 95% CI: 1.01–1.24, p = .03). The meta‐analysis indicated that the overall odds ratio (OR) for all studies was 1.15 (common effect model, 95% CI: 1.08–1.23, p < .01). Sensitivity analysis suggested the absence of heterogeneity and horizontal pleiotropy in all MR analyses.ConclusionBased on bidirectional two‐sample MR analysis, there is an indication that elevated eosinophil count may increase the risk of UC. However, potential confounding factors cannot be ruled out, and further research is necessary to explore how eosinophils contribute to the onset and progression of UC.
Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
https://orcid.org/0009-0006-2073-5233
https://orcid.org/0009-0002-1507-3600
AbstractBackgroundObservational studies have indicated that peripheral blood eosinophil count is elevated in individuals diagnosed with ulcerative colitis (UC) and correlates with the disease activity of UC. However, this conclusion contradicts with findings from other studies. Therefore, we employed Mendelian randomization (MR) method to assess the genetic link between eosinophil count and UC.MethodThis MR study utilized summary data from genome‐wide association studies (GWAS) on eosinophil count and UC. The main approach used for conducting MR analysis was the inverse variance weighted (IVW) method. Meta‐analysis of the IVW results was performed alongside multiple sensitivity analyses to confirm the robustness of the MR analysis results.ResultsThe IVW method unveiled a causal relationship between eosinophil count and UC (OR = 1.18, 95% CI: 1.04–1.33, p = .01) in the discovery cohort. This finding was further corroborated by the replication cohorts (OR = 1.16, 95% CI: 1.04–1.29, p = .01; OR = 1.12, 95% CI: 1.01–1.24, p = .03). The meta‐analysis indicated that the overall odds ratio (OR) for all studies was 1.15 (common effect model, 95% CI: 1.08–1.23, p < .01). Sensitivity analysis suggested the absence of heterogeneity and horizontal pleiotropy in all MR analyses.ConclusionBased on bidirectional two‐sample MR analysis, there is an indication that elevated eosinophil count may increase the risk of UC. However, potential confounding factors cannot be ruled out, and further research is necessary to explore how eosinophils contribute to the onset and progression of UC.
Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
Environmental Toxicology
Shao, Yijia (author) / Liu, Cong (author) / Wang, Xiuqi (author) / Zhou, Wei (author)
Environmental Toxicology ; 39 ; 4669-4676
2024-10-01
Article (Journal)
Electronic Resource
English
Guidebook for ulcerative colitis
| British Library Online Contents | 1999
Urgent proctocolectomy in ulcerative colitis
| British Library Conference Proceedings | 1997