A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
https://orcid.org/0000-0001-6131-5039
https://orcid.org/0000-0002-8287-5040
https://orcid.org/0000-0002-7704-7419
https://orcid.org/0000-0003-4316-5350
https://orcid.org/0000-0002-2553-2068
https://orcid.org/0000-0001-7777-079X
https://orcid.org/0000-0003-4962-5186
https://orcid.org/0000-0002-8806-322X
AbstractPentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited‐state properties. Herein, a synthetic approach for attaching aryl substituents at the C2’ position of the thio‐pentamethine cyanine (TCy5) dye structure is reported for the first time. C2’‐aryl substitution enables the regulation of both the twisted intramolecular charge transfer (TICT) and photoinduced electron transfer (PET) mechanisms to be regulated in the excited state. Modulation of these mechanisms allows the design of a nitroreductase‐activatable TCy5 fluorophore for hypoxic tumor photodynamic therapy and fluorescence imaging. These C2’‐aryl TCy5 dyes provide a tunable platform for engineering cyanine dyes tailored to sophisticated biological applications, such as photodynamic therapy.
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
https://orcid.org/0000-0001-6131-5039
https://orcid.org/0000-0002-8287-5040
https://orcid.org/0000-0002-7704-7419
https://orcid.org/0000-0003-4316-5350
https://orcid.org/0000-0002-2553-2068
https://orcid.org/0000-0001-7777-079X
https://orcid.org/0000-0003-4962-5186
https://orcid.org/0000-0002-8806-322X
AbstractPentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited‐state properties. Herein, a synthetic approach for attaching aryl substituents at the C2’ position of the thio‐pentamethine cyanine (TCy5) dye structure is reported for the first time. C2’‐aryl substitution enables the regulation of both the twisted intramolecular charge transfer (TICT) and photoinduced electron transfer (PET) mechanisms to be regulated in the excited state. Modulation of these mechanisms allows the design of a nitroreductase‐activatable TCy5 fluorophore for hypoxic tumor photodynamic therapy and fluorescence imaging. These C2’‐aryl TCy5 dyes provide a tunable platform for engineering cyanine dyes tailored to sophisticated biological applications, such as photodynamic therapy.
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
https://orcid.org/0000-0001-6131-5039
https://orcid.org/0000-0002-8287-5040
https://orcid.org/0000-0002-7704-7419
https://orcid.org/0000-0003-4316-5350
https://orcid.org/0000-0002-2553-2068
https://orcid.org/0000-0001-7777-079X
https://orcid.org/0000-0003-4962-5186
https://orcid.org/0000-0002-8806-322X
AbstractPentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited‐state properties. Herein, a synthetic approach for attaching aryl substituents at the C2’ position of the thio‐pentamethine cyanine (TCy5) dye structure is reported for the first time. C2’‐aryl substitution enables the regulation of both the twisted intramolecular charge transfer (TICT) and photoinduced electron transfer (PET) mechanisms to be regulated in the excited state. Modulation of these mechanisms allows the design of a nitroreductase‐activatable TCy5 fluorophore for hypoxic tumor photodynamic therapy and fluorescence imaging. These C2’‐aryl TCy5 dyes provide a tunable platform for engineering cyanine dyes tailored to sophisticated biological applications, such as photodynamic therapy.
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
Advanced Science
Han, Fuping (author) / Abbas Abedi, Syed Ali (author) / He, Shan (author) / Zhang, Han (author) / Long, Saran (author) / Zhou, Xiao (author) / Chanmungkalakul, Supphachok (author) / Ma, He (author) / Sun, Wen (author) / Liu, Xiaogang (author)
Advanced Science ; 11
2024-02-01
Article (Journal)
Electronic Resource
English
Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica
| Wiley | 2025
Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica
| Wiley | 2025
Exciton Band Structures in 2D Aggregates of Cyanine Dyes
| British Library Online Contents | 1995