A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
One‐Pot Synthesis of Oxygen Vacancy‐Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic‐Immunotherapy
https://orcid.org/0000-0002-9622-0870
AbstractRadiodynamic therapy that employs X‐rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO4) shows great potential as a radiodynamic agent benefiting from its strong X‐ray absorption and the ability to generate electron–hole (e−‐h+) pairs, slow charge carrier transfer and fast e−‐h+ recombination greatly limit its ROS‐generating performance. Herein, via a one‐pot wet‐chemical method, oxygen vacancy‐rich amorphous/crystalline heterophase CaWO4 nanoparticles (Ov‐a/c‐CaWO4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic‐immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e−‐h+ recombination, respectively, enabling synergistically improved ROS production from X‐ray‐irradiated Ov‐a/c‐CaWO4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic‐immunotherapeutic anticancer nanoagents.
One‐Pot Synthesis of Oxygen Vacancy‐Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic‐Immunotherapy
https://orcid.org/0000-0002-9622-0870
AbstractRadiodynamic therapy that employs X‐rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO4) shows great potential as a radiodynamic agent benefiting from its strong X‐ray absorption and the ability to generate electron–hole (e−‐h+) pairs, slow charge carrier transfer and fast e−‐h+ recombination greatly limit its ROS‐generating performance. Herein, via a one‐pot wet‐chemical method, oxygen vacancy‐rich amorphous/crystalline heterophase CaWO4 nanoparticles (Ov‐a/c‐CaWO4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic‐immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e−‐h+ recombination, respectively, enabling synergistically improved ROS production from X‐ray‐irradiated Ov‐a/c‐CaWO4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic‐immunotherapeutic anticancer nanoagents.
One‐Pot Synthesis of Oxygen Vacancy‐Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic‐Immunotherapy
https://orcid.org/0000-0002-9622-0870
AbstractRadiodynamic therapy that employs X‐rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO4) shows great potential as a radiodynamic agent benefiting from its strong X‐ray absorption and the ability to generate electron–hole (e−‐h+) pairs, slow charge carrier transfer and fast e−‐h+ recombination greatly limit its ROS‐generating performance. Herein, via a one‐pot wet‐chemical method, oxygen vacancy‐rich amorphous/crystalline heterophase CaWO4 nanoparticles (Ov‐a/c‐CaWO4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic‐immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e−‐h+ recombination, respectively, enabling synergistically improved ROS production from X‐ray‐irradiated Ov‐a/c‐CaWO4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic‐immunotherapeutic anticancer nanoagents.
One‐Pot Synthesis of Oxygen Vacancy‐Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic‐Immunotherapy
Advanced Science
Peng, Shanshan (author) / Chen, Zhen (author) / Wang, Jun (author) / Yu, Meili (author) / Niu, Xuegang (author) / Cui, Tingting (author) / Ao, Rujiang (author) / Cai, Huilan (author) / Huang, Hongwei (author) / Lin, Lisen (author)
Advanced Science ; 12
2025-02-01
Article (Journal)
Electronic Resource
English
| British Library Online Contents | 2012