A platform for research: civil engineering, architecture and urbanism
Bayesian benchmark dose analysis
An important objective in environmental risk assessment is the estimation of minimum exposure levels called benchmark doses (BMDs), which induce a pre‐specified benchmark response in a target population. Established inferential approaches for BMD analysis typically involve one‐sided, frequentist confidence limits, leading in practice to what are called benchmark dose lower Limits (BMDLs). Appeal to Bayesian modeling and credible limits for building BMDLs is far less developed, however. Indeed, for the few existing forms of Bayesian BMDs, informative prior information is seldom incorporated. We develop reparameterized quantal‐response models that explicitly describe the BMD as a target parameter. Our goal is to obtain an improved estimation and calculation archetype for the BMD and for the BMDL by quantifying prior beliefs representing parameter uncertainty in the statistical model. Implementation is facilitated via a Monte Carlo‐based adaptive Metropolis algorithm to approximate the posterior distribution. An example from environmental carcinogenicity testing illustrates the methodology. Copyright © 2015 John Wiley & Sons, Ltd.
Bayesian benchmark dose analysis
An important objective in environmental risk assessment is the estimation of minimum exposure levels called benchmark doses (BMDs), which induce a pre‐specified benchmark response in a target population. Established inferential approaches for BMD analysis typically involve one‐sided, frequentist confidence limits, leading in practice to what are called benchmark dose lower Limits (BMDLs). Appeal to Bayesian modeling and credible limits for building BMDLs is far less developed, however. Indeed, for the few existing forms of Bayesian BMDs, informative prior information is seldom incorporated. We develop reparameterized quantal‐response models that explicitly describe the BMD as a target parameter. Our goal is to obtain an improved estimation and calculation archetype for the BMD and for the BMDL by quantifying prior beliefs representing parameter uncertainty in the statistical model. Implementation is facilitated via a Monte Carlo‐based adaptive Metropolis algorithm to approximate the posterior distribution. An example from environmental carcinogenicity testing illustrates the methodology. Copyright © 2015 John Wiley & Sons, Ltd.
Bayesian benchmark dose analysis
Fang, Q. (author) / Piegorsch, W. W. (author) / Barnes, K. Y. (author)
Environmetrics ; 26 ; 373-382
2015-08-01
10 pages
Article (Journal)
Electronic Resource
English
A computational system for Bayesian benchmark dose estimation of genomic data in BBMD
DOAJ | 2022
|Quantile benchmark dose estimation for continuous endpoints
Wiley | 2015
|